PARK7_HUMAN Q99497
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UniProt:Q99497
Recommended name：Parkinson disease protein 7
EC number：EC:3.1.2.-
Alternative names：(Maillard deglycase) (Oncogene DJ1) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1)
Cleaved into：
GeneID：11315
Gene names (primary )：PARK7
Gene names (synonym )：
Gene names (ORF )：
Length：189
Mass：19891
Sequence：MASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIVEALNGKEVAAQVKAPLVLKD
Tissue specificity：Highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart. Detected at slightly lower levels in placenta and brain (at protein level). Detected in astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa. Expressed by pancreatic islets at higher levels than surrounding exocrine tissues (PubMed:22611253). {ECO:0000269|PubMed:14579415, ECO:0000269|PubMed:14662519, ECO:0000269|PubMed:14705119, ECO:0000269|PubMed:22611253, ECO:0000269|PubMed:9070310}.
Induction：By hydrogen peroxide and UV irradiation (PubMed:14749723, PubMed:15976810). In pancreatic islets, expression increases under hyperglycemic conditions (PubMed:22611253). Expression is also induced by sulforaphane, an isothiocyanate obtained from cruciferous vegetables (PubMed:26995087). {ECO:0000269|PubMed:14749723, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:22611253, ECO:0000269|PubMed:26995087}.
Developmental stage：In pancreatic islets, expression increases during aging. {ECO:0000269|PubMed:22611253}.
Protein families：Peptidase C56 family