HACD1_HUMAN B0YJ81
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UniProt:B0YJ81
Recommended name：Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1
EC number：EC:4.2.1.134
Alternative names：(3-hydroxyacyl-CoA dehydratase 1) (HACD1) (Cementum-attachment protein) (CAP) (Protein-tyrosine phosphatase-like member A)
Cleaved into：
GeneID：9200
Gene names (primary )：HACD1
Gene names (synonym )：PTPLA
Gene names (ORF )：
Length：288
Mass：32388
Sequence：MGRLTEAAAAGSGSRAAGWAGSPPTLLPLSPTSPRCAATMASSDEDGTNGGASEAGEDREAPGERRRLGVLATAWLTFYDIAMTAGWLVLAIAMVRFYMEKGTHRGLYKSIQKTLKFFQTFALLEIVHCLIGIVPTSVIVTGVQVSSRIFMVWLITHSIKPIQNEESVVLFLVAWTVTEITRYSFYTFSLLDHLPYFIKWARYNFFIILYPVGVAGELLTIYAALPHVKKTGMFSIRLPNKYNVSFDYYYFLLITMASYIPLFPQLYFHMLRQRRKVLHGEVIVEKDD
Tissue specificity：Isoform 1 is highly expressed in the myocardium, and to a lesser extent in skeletal and smooth muscular tissues including those from stomach, jejunum, and bladder. Also detected in gingival fibroblasts, periodontal ligament cells, osteoblasts and cementoblasts (PubMed:11054553, PubMed:22067203). Isoform 2 is specifically expressed by cementoblasts but also detected in periodontal ligament cells, heart, liver and kidney (at protein level) (PubMed:22067203). {ECO:0000269|PubMed:11054553, ECO:0000269|PubMed:22067203}.
Induction：
Developmental stage：Isoform 1 is expressed in fetal heart. {ECO:0000269|PubMed:11054553}.
Protein families：Very long-chain fatty acids dehydratase HACD family