MEST_HUMAN Q5EB52
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UniProt:Q5EB52
Recommended name：Mesoderm-specific transcript homolog protein
EC number：EC:3.-.-.-
Alternative names：(Paternally-expressed gene 1 protein)
Cleaved into：
GeneID：4232
Gene names (primary )：MEST
Gene names (synonym )：PEG1
Gene names (ORF )：
Length：335
Mass：38830
Sequence：MVRRDRLRRMREWWVQVGLLAVPLLAAYLHIPPPQLSPALHSWKSSGKFFTYKGLRIFYQDSVGVVGSPEIVVLLHGFPTSSYDWYKIWEGLTLRFHRVIALDFLGFGFSDKPRPHHYSIFEQASIVEALLRHLGLQNRRINLLSHDYGDIVAQELLYRYKQNRSGRLTIKSLCLSNGGIFPETHRPLLLQKLLKDGGVLSPILTRLMNFFVFSRGLTPVFGPYTRPSESELWDMWAGIRNNDGNLVIDSLLQYINQRKKFRRRWVGALASVTIPIHFIYGPLDPVNPYPEFLELYRKTLPRSTVSILDDHISHYPQLEDPMGFLNAYMGFINSF
Tissue specificity：Highly expressed in hydatidiform moles, but barely expressed in dermoid cysts. Biallelic expression is detected in blood lymphocytes. Seems to imprinted in an isoform-specific manner rather than in a tissue-specific manner in lymphocytes. Isoform 1 is expressed only from the paternal allele. Isoform 2 is expressed from both the paternal allele and the maternal allele. {ECO:0000269|PubMed:8884280, ECO:0000269|PubMed:9192843}.
Induction：
Developmental stage：Monoallelic expression of paternally derived allele was observed in all fetal tissues examined, including brain, skeletal muscle, kidney, adrenal, tongue, heart, skin and placenta. In 75-day fetus, expressed in the amnion, brain, heart, lung, stomach, gut, adrenal, kidney, muscle and liver. {ECO:0000269|PubMed:8884280, ECO:0000269|PubMed:9158153, ECO:0000269|PubMed:9192843}.
Protein families：AB hydrolase superfamily