SIR2_HUMAN Q8IXJ6
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UniProt:Q8IXJ6
Recommended name：NAD-dependent protein deacetylase sirtuin-2
EC number：EC:2.3.1.286
Alternative names：(Regulatory protein SIR2 homolog 2) (SIR2-like protein 2)
Cleaved into：
GeneID：22933
Gene names (primary )：SIRT2
Gene names (synonym )：SIR2L SIR2L2
Gene names (ORF )：
Length：389
Mass：43182
Sequence：MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
Tissue specificity：Isoform 1 is expressed in heart, liver and skeletal muscle, weakly expressed in the cortex. Isoform 2 is strongly expressed in the cortex, weakly expressed in heart and liver. Weakly expressed in several malignancies including breast, liver, brain, kidney and prostate cancers compared to normal tissues. Weakly expressed in glioma cell lines compared to normal brain tissues (at protein level). Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. {ECO:0000269|PubMed:10381378, ECO:0000269|PubMed:10393250, ECO:0000269|PubMed:12963026, ECO:0000269|PubMed:16909107, ECO:0000269|PubMed:21791548, ECO:0000269|PubMed:22014574}.
Induction：Up-regulated in response to low levels of glucose and anoxia-reoxygenation stress. Up-regulated by trichostatin A. Down-regulated in response to high levels of glucose. Down-regulated by histone deacetylation in several tumors. {ECO:0000269|PubMed:16909107, ECO:0000269|PubMed:18640115, ECO:0000269|PubMed:21726808}.
Developmental stage：Peaks during mitosis. After mitosis, it is probably degraded by the 26S proteasome. {ECO:0000269|PubMed:12697818}.
Protein families：Sirtuin family, Class I subfamily