AL9A1_HUMAN P49189
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UniProt:P49189
Recommended name：4-trimethylaminobutyraldehyde dehydrogenase
EC number：EC:1.2.1.47
Alternative names：(TMABA-DH) (TMABALDH) (Aldehyde dehydrogenase E3 isozyme) (Aldehyde dehydrogenase family 9 member A1) (Gamma-aminobutyraldehyde dehydrogenase) (R-aminobutyraldehyde dehydrogenase)
Cleaved into：4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed
GeneID：223
Gene names (primary )：ALDH9A1
Gene names (synonym )：ALDH4 ALDH7 ALDH9
Gene names (ORF )：
Length：494
Mass：53802
Sequence：MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVESAF
Tissue specificity：Detected in brain (at protein level) (PubMed:8645224). High expression in adult liver, skeletal muscle, and kidney. Low levels in heart, pancreas, lung and brain (PubMed:8786138). Expressed in all regions of the brain. Expression levels are variable in the different brain areas, with the highest levels in the spinal cord and the lowest in the occipital pole. {ECO:0000269|PubMed:8645224, ECO:0000269|PubMed:8786138}.
Induction：
Developmental stage：Strongly expressed in human embryonic brain (gestational age 12 weeks).
Protein families：Aldehyde dehydrogenase family