SGMR1_MOUSE O55242
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UniProt:O55242
Recommended name:Sigma non-opioid intracellular receptor 1
EC number:
Alternative names:(Sigma 1-type opioid receptor) (Sigma1-receptor) (Sigma1R)
Cleaved into:
GeneID:18391
Gene names (primary ):Sigmar1
Gene names (synonym ):Oprs1
Gene names (ORF ):
Length:223
Mass:25250
Sequence:MPWAAGRRWAWITLILTIIAVLIQAAWLWLGTQNFVFSREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCILHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWKEGTTKSEVFYPGETVVHGPGEATALEWGPNTWMVEYGRGVIPSTLFFALADTFFSTQDYLTLFYTLRAYARGLRLELTTYLFGQDS
Tissue specificity:Widely expressed with higher expression in liver, brain, kidney and thymus. Expressed throughout the brain with higher expression within cerebral cortex, hippocampus and cerebellum. Within the hippocampus expressed in cornu ammonis pyramidal neurons, the granular cells of the dentate gyrus as well as interneurons. Within the cerebellum, expressed in Purkinje cell bodies (PubMed:11207432, PubMed:11476895, PubMed:11687279, PubMed:9603192). Highly expressed in the brainstem and motor neurons of the spinal cord (PubMed:20167253). Expressed by neural retina, retinal pigment epithelial cells and lens (PubMed:11207432, PubMed:11476895, PubMed:11687279, PubMed:9603192). {ECO:0000269|PubMed:11207432, ECO:0000269|PubMed:11476895, ECO:0000269|PubMed:11687279, ECO:0000269|PubMed:20167253, ECO:0000269|PubMed:9603192}.
Induction:
Developmental stage:
Protein families:ERG2 family