TKN4_MOUSE Q99N14
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UniProt:Q99N14
Recommended name:Tachykinin-4
EC number:
Alternative names:(Preprotachykinin-C) (PPT-C)
Cleaved into:Hemokinin (HK1) (Hemokinin-1) (Hemokinin-I) (HK-I)
GeneID:93670
Gene names (primary ):Tac4
Gene names (synonym ):
Gene names (ORF ):
Length:128
Mass:13937
Sequence:MLPLLALLLLIGPSVCTTAGDREELAFGAEAESWVTVNLKGIPVPSIELKLQELKRSRTRQFYGLMGKRVGGYQLGRIVQDLLGTRGLSIEGTCRQAASQQRARPGAVTRESLQSREEDEAPLTTSNV
Tissue specificity:Expressed in hematopoietic cells with highest levels in pre- and pro-B cells but not in later developmental stages. Also detected in uterus, skeletal muscle, brain, spleen, stomach, skin and lactating mammary gland and in cells of myeloid lineage including dendritic and microglial cells and macrophages. In uterus, highest expression is observed in non-pregnant diestrus mice and in day 5 pregnant mice. Compared with mice in diestrus, decreases 2.6-fold in uteri from non-pregnant mice in estrus and 10.2-fold in day 17 pregnant mice. Detected at sites of chronic inflammation such as granulomas. {ECO:0000269|PubMed:11062498, ECO:0000269|PubMed:12383518, ECO:0000269|PubMed:12716968, ECO:0000269|PubMed:12842130, ECO:0000269|PubMed:15153465, ECO:0000269|PubMed:15342200, ECO:0000269|PubMed:15647454}.
Induction:
Developmental stage:
Protein families:Tachykinin family