ENDOU_MOUSE Q3V188
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UniProt:Q3V188
Recommended name:Poly(U)-specific endoribonuclease
EC number:EC 3.1.-.-
Alternative names:(Placental protein 11-related protein) (PP11-related protein) (Protein endoU) (T-cell-specific protein 30) (Tcl-30) (Uridylate-specific endoribonuclease)
Cleaved into:
GeneID:19011
Gene names (primary ):Endou
Gene names (synonym ):Pp11r
Gene names (ORF ):
Length:412
Mass:47010
Sequence:MKARVPFIVAMLCGLAWAGNLESCASRCHEKFNRDAVCQCDRRCPQHDDCCDDYEHLCTAEEGPPEPEAFLDPEDKIPTSHLYSAPSSCQGRCREAYDKHHPCHCNDRCPEFGNCCEDFDSLCGGDHEGFSHSSDAVTKEELESISETIYRVDTNKAQKEDIVLNSQNRISPSETGNQVDRSPEPLFTYVNEKLFSKPTYAAFINLLNNYQRATGHGEHFSAQQLEEQGVFLREVMKTAVMKELYSFLHHQNRYSSEQEFVDDLKNMWFGLYSRGNDEGDSSGFEHVFSGEVKKGKVTGFHNWIRFYLQEKEGLLDYYSHNYDGPWDSYPDVLAMQFNWDGYYKEVGSVFIGSSPEFEFALYSLCFITRPGKKCHLSLGGYPLAIQTYTWDKTTYGNGKKYIATAYVVSSSQ
Tissue specificity:Specifically expressed in T-cells during apoptosis. Expressed in surface heat stable antigen (HSA)-containing T-cells populations (CD4(-)CD8(-)HSA(+), CD4(+)CD8(-)HSA(+), CD4(-)CD8(+)HSA(+), and CD4(+)CD8(+)HSA(+)) and not in the HSA(-) single positive T-cell populations of the thymus or spleen, suggesting that expression is lost during T-cell maturation and is absent at the most mature stages of T-cell development. {ECO:0000269|PubMed:1506680, ECO:0000269|PubMed:8104059}.
Induction:
Developmental stage:
Protein families:ENDOU family