HAVR2_MOUSE Q8VIM0
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UniProt:Q8VIM0
Recommended name：Hepatitis A virus cellular receptor 2 homolog
EC number：
Alternative names：(HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)
Cleaved into：
GeneID：171285
Gene names (primary )：Havcr2
Gene names (synonym )：Tim3 Timd3
Gene names (ORF )：
Length：281
Mass：30934
Sequence：MFSGLTLNCVLLLLQLLLARSLENAYVFEVGKNAYLPCSYTLSTPGALVPMCWGKGFCPWSQCTNELLRTDERNVTYQKSSRYQLKGDLNKGDVSLIIKNVTLDDHGTYCCRIQFPGLMNDKKLELKLDIKAAKVTPAQTAHGDSTTASPRTLTTERNGSETQTLVTLHNNNGTKISTWADEIKDSGETIRTAIHIGVGVSAGLTLALIIGVLILKWYSCKKKKLSSLSLITLANLPPGGLANAGAVRIRSEENIYTIEENVYEVENSNEYYCYVNSQQPS
Tissue specificity：Expressed in T-helper type 1 lymphocytes. Not expressed by naive T-cells but up-regulated as they differentiate into T-helper-1 cells. Also expressed by differentiated type 1 CD8+ cytotoxic T-cells. Expressed on peritoneal exudate macrophages, monocytes, and splenic dendritic cells (DCs). Expression on natural killer (NK) cells is inversely associated with IFN-gamma production during the initial 24 h of LPS-induced endotoxic shock. Expressed on mast cells. {ECO:0000269|PubMed:11823861, ECO:0000269|PubMed:14556006, ECO:0000269|PubMed:17620455, ECO:0000269|PubMed:19224762, ECO:0000269|PubMed:24567532, ECO:0000269|PubMed:25337993}.
Induction：
Developmental stage：
Protein families：Immunoglobulin superfamily, TIM family