M3K12_MOUSE Q60700
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UniProt:Q60700
Recommended name：Mitogen-activated protein kinase kinase kinase 12
EC number：EC 2.7.11.25
Alternative names：(Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase)
Cleaved into：
GeneID：26404
Gene names (primary )：Map3k12
Gene names (synonym )：Zpk
Gene names (ORF )：
Length：888
Mass：96084
Sequence：MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTQCVLRDVVPLGGQGGGGPSPSPGGEPPPEPFANSVLQLHEQDTGGPGGATGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKSHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRAALPPHEPGGLGSPGGLGVGPSAWDACPPALRGLHHDLLLRKMSSSSPDLLSAALGARGRGATGGARDPGSPPPPQGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTAGRGGNRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELPPSQRWPQGPNMRQSLSTFSSENPSDVEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDLPTSEVVPEREASSLPMQHQDGQGPNPEDSDCDSTELDNSNSIDALRPPASLPP
Tissue specificity：Within the nervous system, predominantly expressed in neurons and enriched in synaptic terminals (PubMed:8663324). Expressed in brain, kidney, lung, heart, testis, gastrointestinal tract, stomach, liver and pancreas (PubMed:8769565, PubMed:7983011). {ECO:0000269|PubMed:7983011, ECO:0000269|PubMed:8663324, ECO:0000269|PubMed:8769565}.
Induction：
Developmental stage：
Protein families：Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily