CRTAM_MOUSE Q149L7
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UniProt:Q149L7
Recommended name：Cytotoxic and regulatory T-cell molecule
EC number：
Alternative names：(Class-I MHC-restricted T-cell-associated molecule) (CD antigen CD355)
Cleaved into：
GeneID：54698
Gene names (primary )：Crtam
Gene names (synonym )：
Gene names (ORF )：
Length：393
Mass：43907
Sequence：MWWGALSLLFWVPVQAAFLKMETVTVEEGQTLTLTCVTSQTKNVSLQWLAPSGFTIFLNQHPALKSSKYQLLHHSATQLSISVSNVTLREEGVYTCLHYGSSVKTKQVRVTVLVTPFQPTVEALVLRRQNGEKSVVLKCSTERSKPPPQITWLLGEGLEIYGELNHEFEADGKICNTSSMLIARAYGKNSTVHCIIQHEGLHGRKLVAPFQFEDLVADQETSDQETSDAPEQSSLSSQALQQPTSTVSMMENSSIPETDKEEKEHATQDPGLSTEASAQHTGLARRKSGILLLTLVSFLIFILFIIVQLFIMKLRKAHVVWKKESEISEQALESYRSRSNNEETSSQENSSQAPQSKRCMNYITRLYSGAKTKKSAQHWKLGGKHSRVPESIV
Tissue specificity：In the immune system, expression is restricted to activated class-I MHC-restricted cells, including NKT, NK and CD8+ T-cells (at protein level) (PubMed:10811014, PubMed:15811952, PubMed:18329370, PubMed:19752223). Transiently expressed in activated CD8+ T-cells and a subset of activated CD4+ T-cells (at protein level) (PubMed:18329370). Expressed in activated intestinal T-cells, specifically intraepithelial CD4+ CD8+ T-cells, intraepithelial CD4+ T-cells and, CD8+ T-cells in the intestine epithelium, lamina propria, Peyer's Patches and mesenteric lymph nodes (PubMed:24687959). Also expressed in spleen, brain and testis (PubMed:10811014). {ECO:0000269|PubMed:10811014, ECO:0000269|PubMed:15811952, ECO:0000269|PubMed:18329370, ECO:0000269|PubMed:19752223, ECO:0000269|PubMed:24687959}.
Induction：
Developmental stage：
Protein families：Nectin family