CP46A_MOUSE Q9WVK8
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UniProt:Q9WVK8
Recommended name：Cholesterol 24-hydroxylase
EC number：EC 1.14.14.25
Alternative names：(CH24H) (Cholesterol 24-monooxygenase) (Cholesterol 24S-hydroxylase) (Cytochrome P450 46A1)
Cleaved into：
GeneID：13116
Gene names (primary )：Cyp46a1
Gene names (synonym )：Cyp46
Gene names (ORF )：
Length：500
Mass：56814
Sequence：MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPYFWKKDEDCGRVLQDVFLDWAKKYGPVVRVNVFYKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECDYGRWYKQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTCATIDILAKAAFGMETSMLLGAQKPLSQAVKVMLEGISASRNTLAKFMPGKRKQLREIRESIRLLRQVGKDWVQRRREALKRGEDMPADILTQILKAEEGAQDDEVLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRHLDYEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPPPPPC
Tissue specificity：Expressed in high level in the pyramidal cells of the hippocampus, Purkinje cells of the cerebellum, and neuronal cell bodies in layers II/III, V, and VI of the cortex. Expressed in hippocampal and cerebellar interneurons, in retinal ganglion cells, and in a subset of retinal cells localized to the inner nuclear layer (at protein level). {ECO:0000269|PubMed:10377398, ECO:0000269|PubMed:18241055}.
Induction：
Developmental stage：
Protein families：Cytochrome P450 family