PDE1C_MOUSE Q64338
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UniProt:Q64338
Recommended name：Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
EC number：EC 3.1.4.-
Alternative names：(Cam-PDE 1C) (3',5'-cyclic-AMP phosphodiesterase) (3',5'-cyclic-GMP phosphodiesterase) (EC 3.1.4.35)
Cleaved into：
GeneID：18575
Gene names (primary )：Pde1c
Gene names (synonym )：
Gene names (ORF )：
Length：706
Mass：80290
Sequence：MESPTKEIEEFESNSLKHLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIDALKDVDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDESSQTGGTGQRRSSLNSINSSDAKRSGVKSSGSDGSAPINNSVIPVDYKSFKATWTEVVQINRERWRAKVPKEEKAKKEAEEKARLAAEEKQKEMEAKSQAEQGTTSKGEKKTSGEAKSQVNGTRKGDNPRGKNSKGEKAGEKQQNGDLKDGKNKADKKDHSNTGNESKKTDGTKKRSHGSPAPSTSSTSRITLPVIKPPLRHFKRPAYASSSYAPSVPKKTDDHPVRYKMLDQRIKMKKIQNISHHWNKK
Tissue specificity：Isoform 1 is highly expressed in testis and at moderate levels in heart (PubMed:8810348). Isoform 2 is expressed at a moderate level in brain, the cerebellum, testis, heart and olfactory epithelium (PubMed:8810348). Isoform 3 highly expressed in olfactory epithelium and at very low levels, if any, in other tissues (PubMed:8810348). In the cochlea, expressed in the inner and outer hair cells (at protein level) (PubMed:29860631). In the brain, highly expressed in the neurons of the granule layer of the cerebellum, some Purkinje cells, the central amygdaloid nucleus, and the interpolar spinal trigem nucleus and, at moderate levels, in the glomerular and external plexiform layer of the olfactory bulb as well as in parts of the caudate-putamen and olfactory tubercle (PubMed:8810348). {ECO:0000269|PubMed:29860631, ECO:0000269|PubMed:8810348}.
Induction：
Developmental stage：
Protein families：Cyclic nucleotide phosphodiesterase family, PDE1 subfamily