AQP4_MOUSE P55088
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UniProt:P55088
Recommended name:Aquaporin-4
EC number:
Alternative names:(AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4)
Cleaved into:
GeneID:11829
Gene names (primary ):Aqp4
Gene names (synonym ):
Gene names (ORF ):
Length:323
Mass:34436
Sequence:MSDGAAARRWGKCGHSCSRESIMVAFKGVWTQAFWKAVSAEFLATLIFVLLGVGSTINWGGSENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIIAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWANHWIYWVGPIMGAVLAGALYEYVFCPDVELKRRLKEAFSKAAQQTKGSYMEVEDNRSQVETEDLILKPGVVHVIDIDRGEEKKGKDSSGEVLSSV
Tissue specificity:Detected in brain cortex, especially around cortical blood vessels, and subjacent to pia, with lower levels in parenchymal membranes (PubMed:27751903). Detected in ependymal and astroglial cells in brain (PubMed:8660998, PubMed:9276712, PubMed:22896675, PubMed:27751903). Detected in supporting Hensen's cells, inner sulcus cells and Claudius cells in the inner ear (PubMed:11406631). Detected in skeletal muscle (PubMed:29055082). Detected in gastric parietal cells (PubMed:10915655). Detected in principal cells in collecting ducts in kidney medulla (at protein level) (PubMed:9276712, PubMed:16641094). Detected in brain, heart and skeletal muscle (PubMed:8660998). {ECO:0000269|PubMed:10915655, ECO:0000269|PubMed:11406631, ECO:0000269|PubMed:16641094, ECO:0000269|PubMed:22896675, ECO:0000269|PubMed:27751903, ECO:0000269|PubMed:29055082, ECO:0000269|PubMed:8660998, ECO:0000269|PubMed:9276712}.
Induction:
Developmental stage:
Protein families:MIP/aquaporin (TC 1.A.8) family