GCR_MOUSE P06537
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UniProt:P06537
Recommended name：Glucocorticoid receptor
EC number：
Alternative names：(GR) (Nuclear receptor subfamily 3 group C member 1)
Cleaved into：
GeneID：14815
Gene names (primary )：Nr3c1
Gene names (synonym )：Grl Grl1
Gene names (ORF )：
Length：783
Mass：86053
Sequence：MDSKESLAPPGRDEVPSSLLGRGRGSVMDLYKTLRGGATVKVSASSPSVAAASQADSKQQRILLDFSKGSASNAQQQQQQQQPQPDLSKAVSLSMGLYMGETETKVMGNDLGYPQQGQLGLSSGETDFRLLEESIANLNRSTSRPENPKSSTPAAGCATPTEKEFPQTHSDPSSEQQNRKSQPGTNGGSVKLYTTDQSTFDILQDLEFSAGSPGKETNESPWRSDLLIDENLLSPLAGEDDPFLLEGDVNEDCKPLILPDTKPKIQDTGDTILSSPSSVALPQVKTEKDDFIELCTPGVIKQEKLGPVYCQASFSGTNIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPVFNVIPPIPVGSENWNRCQGSGEDNLTSLGAMNFAGRSVFSNGYSSPGMRPDVSSPPSSSSTATGPPPKLCLVCSDEASVCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATAGVSQDTSENANKTIVPAALPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSAWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQASGNLLCFAPDLIINEQRMTLPCMYDQCKHMLFISTELQRLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHDVVENLLSYCFQTFLDKSMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
Tissue specificity：Expressed in spleen, kidney and liver. Expressed in a circadian manner in the liver (PubMed:27686098). Isoform 3: Expressed at highest level in spleen with lesser amounts in kidney and liver. {ECO:0000269|PubMed:20660300, ECO:0000269|PubMed:27686098}.
Induction：[Isoform 1]: Down-regulated by glucocorticoids. {ECO:0000269|PubMed:20660300}.; [Isoform 3]: Up-regulated by glucocorticoids and insulin. {ECO:0000269|PubMed:20660300}.
Developmental stage：
Protein families：Nuclear hormone receptor family, NR3 subfamily