PARPT_MOUSE   Q8C1B2


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UniProt:Q8C1B2

Recommended name:Protein mono-ADP-ribosyltransferase TIPARP

EC number:EC 2.4.2.-

Alternative names:(ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (TCDD-inducible poly [ADP-ribose] polymerase)

Cleaved into:

GeneID:99929

Gene names  (primary ):Tiparp

Gene names  (synonym ):

Gene names  (ORF ):

Length:657

Mass:75901

Sequence:MEVETTEPEPDCVVQPPSPSDDFSCQMRISEKISPLKTCFKKKQEQKRLGTGTLRSLRPILNTLLESGSLDGVFRARDQNRDESSLHEHIVKKPLEINPSCPPAENSMPVLIPDGTNVEGQLPEAHPSTDAPEQGVPIQDHSFPPETISGTVADSTTGHFQTDLLHPVSGDVPTSPDCVDKVMDYVPGAFQDNSFTIQYILDTSDKLSTELFQDKSEEASLELVFELVNQLQYHTHQENGIEICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVSNDSQEHLERFYCNPENDRMRMKYGGQDFWADLNAMTVFETTEFDQLRRLSTPPCSNSNSIYHTFWKFFCRDHFGWREYPESVVRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILIPYLQTLGGVPTQASLPLEATSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNLFHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMSGRDRIINERHLFHGTSQDVVDGICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGSHGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI

Tissue specificity:Ubiquitously expressed. {ECO:0000269|PubMed:11716501}.

Induction:By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which is a by-product of industrial processes and an important environmental contaminant (PubMed:11716501, PubMed:12147270). This induction is concentration and time-dependent and is mediated through an aryl hydrocarbon receptor (AhR) and aryl hydrocarbon receptor nuclear translocation (Arnt) signal transduction (PubMed:11716501, PubMed:12147270). Superinduced by cycloheximide and by inhibitors of the 26S proteasome (PubMed:11716501, PubMed:12147270). {ECO:0000269|PubMed:11716501, ECO:0000269|PubMed:12147270}.

Developmental stage:

Protein families:


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