SIR1_MOUSE Q923E4
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UniProt:Q923E4
Recommended name：NAD-dependent protein deacetylase sirtuin-1
EC number：EC 2.3.1.286
Alternative names：(NAD-dependent protein deacylase sirtuin-1) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (SIR2alpha) (Sir2) (mSIR2a)
Cleaved into：SirtT1 75 kDa fragment (75SirT1)
GeneID：93759
Gene names (primary )：Sirt1
Gene names (synonym )：Sir2l1
Gene names (ORF )：
Length：737
Mass：80372
Sequence：MADEVALALQAAGSPSAAAAMEAASQPADEPLRKRPRRDGPGLGRSPGEPSAAVAPAAAGCEAASAAAPAALWREAAGAAASAEREAPATAVAGDGDNGSGLRREPRAADDFDDDEGEEEDEAAAAAAAAAIGYRDNLLLTDGLLTNGFHSCESDDDDRTSHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRILQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRPQKELVHLSELPPTPLHISEDSSSPERTVPQDSSVIATLVDQATNNNVNDLEVSESSCVEEKPQEVQTSRNVENINVENPDFKAVGSSTADKNERTSVAETVRKCWPNRLAKEQISKRLEGNQYLFVPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPLEDESEIEEFYNGLEDDTERPECAGGSGFGADGGDQEVVNEAIATRQELTDVNYPSDKS
Tissue specificity：Widely expressed. Weakly expressed in liver and skeletal muscle. {ECO:0000269|PubMed:12482959}.
Induction：By calorie restriction which induces endothelial nitric oxide synthase (eNOS) expression. Induced in liver by pyruvate during fasting. Expressed in a circadian manner in the liver with maximal and minimal levels reached at around Zeitgeber time (ZT) 16 and ZT4, respectively. Its deacetylase activity in the liver is also regulated in a circadian manner, with a peak at ZT15. Down-regulated by palmitate; palmitate down-regulation is mediated by the induction of miR-195 that directly targets SIRT1. {ECO:0000269|PubMed:15744310, ECO:0000269|PubMed:16224023, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18662547, ECO:0000269|PubMed:21622680}.
Developmental stage：
Protein families：Sirtuin family, Class I subfamily