RN19B_MOUSE A2A7Q9
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UniProt:A2A7Q9
Recommended name：E3 ubiquitin-protein ligase RNF19B
EC number：EC 2.3.2.31
Alternative names：(IBR domain-containing protein 3) (Natural killer lytic-associated molecule) (RING finger protein 19B)
Cleaved into：
GeneID：
Gene names (primary )：Rnf19b
Gene names (synonym )：Ibrdc3 Nklam
Gene names (ORF )：
Length：732
Mass：78127
Sequence：MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTFHSVFSASARGRRARTKPQAEPPPPAAPPPPPPPAPAPVEAQAPPVEALPSEPAAEAEAEAVAAGPEEDEAAEGGGAEEVECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLEVQADVQKEIFPKDTASLGAISDSASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQVAEKEEEGNGAGGGSGGSEDDPPYKHQSCEQKDCLASKAWDISLAQPESIRSDLESSDTQSDDVPDITSDECGSPRSHAAACPSTPQVHGAPSPSAHKNLAAPAEGQTVLKSEEYEVE
Tissue specificity：Expressed specifically in natural killer cells, activated macrophages and cytotoxic T-cells (PubMed:10912506). Present in macrophages (at protein level) (PubMed:10912506). Ubiquitously expressed with high expression in testis (PubMed:27485036). {ECO:0000269|PubMed:10912506, ECO:0000269|PubMed:27485036}.
Induction：By IFNG and LPS in macrophages. By IL2 in natural killer cells and cytotoxic T-cells. {ECO:0000269|PubMed:10912506}.
Developmental stage：
Protein families：RBR family, RNF19 subfamily