PRAF3_MOUSE   Q8R5J9


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UniProt:Q8R5J9

Recommended name:PRA1 family protein 3

EC number:

Alternative names:(ADP-ribosylation factor-like protein 6-interacting protein 5) (ARL-6-interacting protein 5) (Aip-5) (Addicsin) (GTRAP3-18) (Glutamate transporter EAAC1-interacting protein) (Prenylated Rab acceptor protein 2) (Protein JWa)

Cleaved into:

GeneID:65106

Gene names  (primary ):Arl6ip5

Gene names  (synonym ):Aip5 Jwa Pra2 Praf3

Gene names  (ORF ):

Length:188

Mass:21558

Sequence:MDVNLAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQTNYLVVAAMMISVVGFLSPFNMILGGVIVVLVFMGFVWAAHNKDILRRMKKQYPTAFVMVVMLASYFLISMFGGVMVFVFGITLPLLLMFIHASLRLRNLKNKLENKMEGIGLKKTPMGIILDALEQQEDNINKFADYISKARE

Tissue specificity:Expressed in the cerebral cortex, cerebellum, hippocampus, olfactory bulbs, medulla oblongate and limbic system (at protein level) (PubMed:18684713). Ubiquitous. {ECO:0000269|PubMed:12119102, ECO:0000269|PubMed:12438930, ECO:0000269|PubMed:18684713}.

Induction:By methyl-beta-cyclodextrin. Up-regulated upon chronic morphine injection, in amygdala only, other brain regions remain unaffected. Induction by morphine may affect glutamate uptake in the amygdala, causing mice to develop morphine tolerance and dependence (PubMed:12438930). Was originally reported to be induced by retinoic acid (PubMed:12562531). {ECO:0000269|PubMed:12438930, ECO:0000305|PubMed:12562531}.

Developmental stage:

Protein families:PRA1 family


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