PLPL7_MOUSE A2AJ88
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UniProt:A2AJ88
Recommended name：Patatin-like phospholipase domain-containing protein 7
EC number：EC 3.1.1.-
Alternative names：(Neuropathy target esterase-related esterase) (NRE) (NTE-related esterase)
Cleaved into：
GeneID：241274
Gene names (primary )：Pnpla7
Gene names (synonym )：
Gene names (ORF )：
Length：1352
Mass：150494
Sequence：MQNEEDACLEAGYCLGTTLSSWRLHFMEEQSQSTMLMGIGIGALLTLAFVGITFFFVYRRVRRLRRAEPTPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTSAPRQRVRKRTKVLSLAKRILRFKKEYPTLQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGEHVFQPGEPDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSARAAVSSTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNPESQAIPLLSVASVAGRAKRQMSYGPEEQLERSLRPSEFSSSDHGSSCVTVSGPLLKRSCSVPLPSNHGEVDELRQSQGSGSNTSAFQESHEGATSDLGMAYNRARILPHSDEQLGNSLASKSKKSVVAETPSAIFHYSENFRDETGACGKTDAIFRAATKDLLTLMKLDDPSLLDGRVAFLHVPAGTLVSKQGDQDVNILFVVSGMLHVYQQKIDSLEDTCLFLTHPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAHFYEIMRKRPDVVLGVAHTVVKRMSSFVRQIDFALDWMEVEAGRAIYRQGDKSDCTYIVLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGSATGHQLGFNTASSKWDLGNPPGNLSTVAALPASEDVPLTAFALELQHALSAIGPVLLLTSDNIKQRLGSAALDSIHEYRLSSWLGQQEDIHRIVLYQADGTLTPWTQRCIRQADCILIVGLGEQEPAVGELEQMLESTAVRAQKQLILLHKEDGPVPSRTVEWLNMRSWCSGHLHLCCPRRVFSKRSLPKLVEMYTRVFQRPPDRHSDFSRLARMLTGNAIALVLGGGGARGCAQVGILRALAECGVPVDIIGGTSIGAFMGALFAEERSYSQTRIRAKQWAEGMTSMMKTILDLTYPITSMFSGTGFNSSISNIFKDRQIEDLWLPYFAITTDITASAMRVHTDGSLWRYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEMVKNSDYCEYLRPPIDSYRTLDFGKFDEICEVGYQHGRTVFDIWVRSGVLEKMLQDQQGTSKRKDCGVFTCPNSSFTDLAEIVSRIEPAKVAAVDDESDYQTEYEEELPAIPKETYADFQSTGIELDSDSEYEPSMLQGPPSLTSPEQSQDSFPWLPNQDDQGPRLEHPS
Tissue specificity：[Isoform 1]: Expressed in white and brown adipose tissue, cardiac muscle, skeletal muscle, and testis. {ECO:0000269|PubMed:18086666, ECO:0000269|PubMed:22326266}.; [Isoform 2]: Expressed in white adipose tissue, cardiac muscle, skeletal muscle, and testis. {ECO:0000269|PubMed:22326266}.; [Isoform 3]: Expressed in white adipose tissue, cardiac muscle, skeletal muscle, and testis. {ECO:0000269|PubMed:22326266}.
Induction：By nutritional conditions (PubMed:22326266, PubMed:18086666). Expression of isoform 3 is switched to the expression of isoform 2 during fasting (PubMed:22326266). {ECO:0000269|PubMed:18086666, ECO:0000269|PubMed:22326266}.; [Isoform 1]: Expression levels are not affected by fasting. {ECO:0000269|PubMed:22326266}.; [Isoform 2]: In white adipose tissue, cardiac muscle, skeletal muscle, and testis, expression levels are down-regulated under well-fed conditions and are up-regulated during fasting. {ECO:0000269|PubMed:22326266}.; [Isoform 3]: In white adipose tissue, cardiac muscle, skeletal muscle, and testis, expression levels are up-regulated under well-fed conditions and are down-regulated during fasting. {ECO:0000269|PubMed:22326266}.
Developmental stage：
Protein families：NTE family