STEA4_MOUSE Q923B6
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UniProt:Q923B6
Recommended name：Metalloreductase STEAP4
EC number：EC 1.16.1.9
Alternative names：(Dudulin-4) (Six-transmembrane epithelial antigen of prostate 4) (Tumor necrosis factor-alpha-induced adipose-related protein)
Cleaved into：
GeneID：117167
Gene names (primary )：Steap4
Gene names (synonym )：Tiarp
Gene names (ORF )：
Length：470
Mass：52994
Sequence：MEKAHADEFPLTTDSSEKQGVVCIFGTGDFGKSLGLKMLQCGYSIVFGSRNPQVSSLLPRGAEVLSYSEAASKSDIIILAMHREHYDSLTELVDYLKGKVLVDVSNNRKINQYPESNAEYLAQLEPGAHVVKAFNTISAWALQSGTLDASRQVFVCGNDSKAKQRVMDIARTLGLTPLDQGSLMAASEIENYPLQLFPMWRFPFYLSSVLCVFFFVYCAIREVIYPYVNGKTDATYRLAISIPNRVFPITALILLALVYLPGILAAILQLYRGTKYRRFPNWLDHWMLCRKQLGLVALGFAFLHVIYTLVIPIRYYVRWRLRNATITQALTNKDSPFITSYAWINDSYLALGILGFFLFLLLGITSLPSVSNMVNWREFRFVQSKLGYLTLVLCTAHTLVYGGKRFLSPSILRWSLPSAYILALVIPCAVLVLKCILIMPCIDKTLTRIRQGWERNSKYTQSALNGKSDI
Tissue specificity：Expressed in white and brown adipose tissues cells, as well as in muscle and liver cells. Detected in joints and spleens of arthritic mice. {ECO:0000269|PubMed:14988015, ECO:0000269|PubMed:19660107}.
Induction：By Tnfa (TNF-alpha), by Il6 in white and brown adipose tissue, and IL1B in white adipose tissue. Tnfa, Il6 and Il1b shows sinergistic stimulatory effects. {ECO:0000269|PubMed:11443137, ECO:0000269|PubMed:14988015, ECO:0000269|PubMed:17482547, ECO:0000269|PubMed:19289123, ECO:0000269|PubMed:19660107}.
Developmental stage：
Protein families：STEAP family