MDM2_MOUSE P23804
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UniProt:P23804
Recommended name：E3 ubiquitin-protein ligase Mdm2
EC number：EC 2.3.2.27
Alternative names：(Double minute 2 protein) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Cleaved into：
GeneID：17246
Gene names (primary )：Mdm2
Gene names (synonym )：
Gene names (ORF )：
Length：489
Mass：54558
Sequence：MCNTNMSVSTEGAASTSQIPASEQETLVRPKPLLLKLLKSVGAQNDTYTMKEIIFYIGQYIMTKRLYDEKQQHIVYCSNDLLGDVFGVPSFSVKEHRKIYAMIYRNLVAVSQQDSGTSLSESRRQPEGGSDLKDPLQAPPEEKPSSSDLISRLSTSSRRRSISETEENTDELPGERHRKRRRSLSFDPSLGLCELREMCSGGSSSSSSSSSESTETPSHQDLDDGVSEHSGDCLDQDSVSDQFSVEFEVESLDSEDYSLSDEGHELSDEDDEVYRVTVYQTGESDTDSFEGDPEISLADYWKCTSCNEMNPPLPSHCKRCWTLRENWLPDDKGKDKVEISEKAKLENSAQAEEGLDVPDGKKLTENDAKEPCAEEDSEEKAEQTPLSQESDDYSQPSTSSSIVYSSQESVKELKEETQDKDESVESSFSLNAIEPCVICQGRPKNGCIVHGKTGHLMSCFTCAKKLKKRNKPCPVCRQPIQMIVLTYFN
Tissue specificity：Ubiquitously expressed at low-level throughout embryo development and in adult tissues. MDM2-p90 is much more abundant than MDM2-p76 in testis, brain, heart, and kidney, but in the thymus, spleen, and intestine, the levels of the MDM2 proteins are roughly equivalent. {ECO:0000269|PubMed:10075719}.
Induction：By UV light (PubMed:10075719). Down-regulated by NPAS4 (PubMed:25088421). {ECO:0000269|PubMed:10075719, ECO:0000269|PubMed:25088421}.
Developmental stage：
Protein families：MDM2/MDM4 family