LRC33_MOUSE Q8BMT4
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UniProt:Q8BMT4
Recommended name：Transforming growth factor beta activator LRRC33
EC number：
Alternative names：(Leucine-rich repeat-containing protein 33) (Negative regulator of reactive oxygen species)
Cleaved into：
GeneID：224109
Gene names (primary )：Nrros
Gene names (synonym )：Lrrc33
Gene names (ORF )：
Length：693
Mass：77140
Sequence：MEFPPLWLCLGFHFLIVEWRSGPGTATAASQGGCKVVDGVADCRGLNLASVPSSLPPHSRMLILDANPLKDLWNHSLQAYPRLENLSLHSCHLDRISHYAFREQGHLRNLVLADNRLSENYKESAAALHTLLGLRRLDLSGNSLTEDMAALMLQNLSSLEVVSLARNTLMRLDDSIFEGLEHLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNLPCIVDFSLTQLRFLNVSYNILEWFLAAREEVAFELEILDLSHNQLLFFPLLPQCGKLHTLLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQFRHLPDGFLKKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELHLAPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQISLCPQMVPVDWEGPPSCVDFRNMGSLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSNWGVLNGSISPLWAVAPTLQVLSLRDVGLGSGAAEMDFSAFGNLRALDLSGNSLTSFPKFKGSLALRTLDLRRNSLTALPQRVVSEQPLRGLQTIYLSQNPYDCCGVEGWGALQQHFKTVADLSMVTCNLSSKIVRVVELPEGLPQGCKWEQVDTGLFYLVLILPSCLTLLVACTVVFLTFKKPLLQVIKSRCHWSSIY
Tissue specificity：Mainly expressed in cells of hematopoietic origin, such as in immune organs such as lymph nodes, thymus and spleen (PubMed:24739962, PubMed:29909984). Among leukocytes, expressed at higher level in myeloid cell such as macrophages, neutrophils and dendritic cells (PubMed:24739962). Highly expressed in central nervous system-resident macrophages, including microglia and perivascular macrophages (PubMed:28459434, PubMed:29909984). {ECO:0000269|PubMed:24739962, ECO:0000269|PubMed:28459434, ECO:0000269|PubMed:29909984}.
Induction：Down-regulated by IFN-gamma (IFNG), LPS or TNF-alpha in bone marrow-derived macrophages (BMDMs). {ECO:0000269|PubMed:24739962}.
Developmental stage：
Protein families：LRRC32/LRRC33 family