SIGIR_MOUSE Q9JLZ8
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UniProt:Q9JLZ8
Recommended name：Single Ig IL-1-related receptor
EC number：
Alternative names：(Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8)
Cleaved into：
GeneID：24058
Gene names (primary )：Sigirr
Gene names (synonym )：Tir8
Gene names (ORF )：
Length：409
Mass：46159
Sequence：MAGVCDMAPNFLSPSEDQALGLALGREVALNCTAWVFSRPQCPQPSVQWLKDGLALGNGSHFSLHEDFWVSANFSEIVSSVLVLNLTNAEDYGTFTCSVWNVSSHSFTLWRAGPAGHVAAVLASLLVLVVLLLVALLYVKCRLNMLLWYQDTYGEVEMNDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLEDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRPWCSQSFREGLCRLLELTRRPIFITFEGQRREPIHPALRLLRQHRHLVTLVLWKPGSVTPSSDFWKELQLALPRKVQYRPVEGDPQTRLQDDKDPMLIVRGRAAQGRGMESELDPDPEGDLGVRGPVFGEPPTPLQETRICIGESHGSEMDVSDLGSRNYSARTDFYCLVSEDDV
Tissue specificity：Expressed at high levels in kidney, and at moderate levels in colon, small intestine, lung, spleen and liver. Not expressed in brain and muscle. Expressed at high levels in epithelial cells, at moderate levels in splenocytes, and at low or undetectable levels in fibroblasts or endothelial cells. Expressed in mucosal and dendritic cells. {ECO:0000269|PubMed:12925853, ECO:0000269|PubMed:14993616, ECO:0000269|PubMed:21077278}.
Induction：Down-regulated by LPS. Down-regulated during inflammation by inhibition of an SP1-mediated pathway. {ECO:0000269|PubMed:12925853, ECO:0000269|PubMed:21077278}.
Developmental stage：
Protein families：Interleukin-1 receptor family