SPAST_MOUSE Q9QYY8
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UniProt:Q9QYY8
Recommended name：Spastin
EC number：EC 5.6.1.1
Alternative names：
Cleaved into：
GeneID：50850
Gene names (primary )：Spast
Gene names (synonym )：Kiaa1083 Spg4
Gene names (ORF )：
Length：614
Mass：66456
Sequence：MSSPAGRRKKKGSGGASPAPARPPPPAAVPAPAAGPAPAAGSPPKRNPSSFSSPLVVGFALLRLLACHLGLLFAWLCQRFSRALMAAKRSSGTAPAPASPSPPEPGPGGEAESVRVFHKQAFEYISIALRIDEEEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQYERARRLQAKMMTNLVMAKDRLQLLEKLQPVLQFSKSQTDVYNESTNLTCRNGHLQSESGAVPKRKDPLTHASNSLPRSKTVLKSGSAGLSGHHRAPSCSGLSMVSGARPGPGPAATTHKGTPKPNRTNKPSTPTTAVRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQELAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFGDTTV
Tissue specificity：Expressed in brain, heart, liver, lung, skeletal muscle, spinal cord, spleen and testis. {ECO:0000269|PubMed:10610178, ECO:0000269|PubMed:16026783}.
Induction：Expressed is decreased following activation of the Notch pathway by JAG1/Jagged1. {ECO:0000269|PubMed:18495362}.
Developmental stage：
Protein families：AAA ATPase family, Spastin subfamily