SIR4_MOUSE Q8R216
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UniProt:Q8R216
Recommended name：NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
EC number：EC 2.3.1.-
Alternative names：(NAD-dependent ADP-ribosyltransferase sirtuin-4) (NAD-dependent protein deacetylase sirtuin-4) (Regulatory protein SIR2 homolog 4) (SIR2-like protein 4)
Cleaved into：
GeneID：75387
Gene names (primary )：Sirt4
Gene names (synonym )：Sir2l4
Gene names (ORF )：
Length：333
Mass：37525
Sequence：MSGLTFRPTKGRWITHLSRPRSCGPSGLFVPPSPPLDPEKIKELQRFISLSKKLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHIDFVRSAPVRQRYWARNFVGWPQFSSHQPNPAHWALSNWERLGKLHWLVTQNVDALHSKAGSQRLTELHGCMHRVLCLNCGEQTARRVLQERFQALNPSWSAEAQGVAPDGDVFLTEEQVRSFQVPCCDRCGGPLKPDVVFFGDTVNPDKVDFVHRRVKEADSLLVVGSSLQVYSGYRFILTAREQKLPIAILNIGPTRSDDLACLKLDSRCGELLPLIDPRRQHSDVQRLEMNFPLSSAAQDP
Tissue specificity：Detected in kidney, heart, brain, liver and pancreatic islets (at protein level). {ECO:0000269|PubMed:16959573}.
Induction：Expression is directly activated by ATF4/CREB2. In response to mTORC1 signal, expression is down-regulated due to degradation of ATF4/CREB2 (PubMed:23663782). Induced following DNA damage (PubMed:23562301). The expression is strongly inhibited by fasting (PubMed:24043310). {ECO:0000269|PubMed:23562301, ECO:0000269|PubMed:23663782, ECO:0000269|PubMed:24043310}.
Developmental stage：
Protein families：Sirtuin family, Class II subfamily