FSP1_MOUSE Q8BUE4
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UniProt:Q8BUE4
Recommended name：Ferroptosis suppressor protein 1
EC number：EC 1.6.5.-
Alternative names：(FSP1) (Apoptosis-inducing factor homologous mitochondrion-associated inducer of death) (AMID) (p53-responsive gene 3 protein)
Cleaved into：
GeneID：71361
Gene names (primary )：Aifm2
Gene names (synonym )：Amid
Gene names (ORF )：
Length：373
Mass：40635
Sequence：MGSQVSVDTGAVHVVIVGGGFGGIAAASQLQALNVPFMLVDMKDSFHHNVAALRASVESGFAKKTFISYSATFKDNFRQGKVIGIDLKNRMVLLQGGEALPFSHLILATGSTGPFPGKFNEVSCQQAAIQAYEDMVKQIQRSQFIVVVGGGSAGVEMAAEIKTEYPEKEVTLIHSRVPLADKELLPCVRQEVKEILLRKGVQLLLSERVSNLEELPRNEYREYIKVETDKGTEVATNMVIVCNGIKINSSAYRSAFESRLASNGALKVNEFLQVEGYSNIYAIGDCADTKEPKMAYHAGLHANVAVANIVNSMKQRPLKAYKPGALTFLLSMGRNDGVGQISGFYVGRLMVRLAKSRDLLISTSWKTMRQSPP
Tissue specificity：Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in liver, testis, and kidney, and expressed at lower levels in pancreas, spleen, brain and lung (PubMed:16186796). Expressed in heart (at protein level) (PubMed:26689472). {ECO:0000269|PubMed:16186796, ECO:0000269|PubMed:26689472}.
Induction：Expression is up-regulated in mouse embryonic fibroblasts by genotoxic reagents 5-fluorouracil and etoposide (PubMed:16186796). Up-regulated in cardiac cells by anticancer drug doxorubicin (PubMed:26689472). {ECO:0000269|PubMed:16186796, ECO:0000269|PubMed:26689472}.
Developmental stage：
Protein families：FAD-dependent oxidoreductase family