IL6_MOUSE P08505
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UniProt:P08505
Recommended name：Interleukin-6
EC number：
Alternative names：(IL-6) (B-cell hybridoma growth factor) (Interleukin HP-1)
Cleaved into：
GeneID：16193
Gene names (primary )：Il6
Gene names (synonym )：Il-6
Gene names (ORF )：
Length：211
Mass：24384
Sequence：MKFLSARDFHPVAFLGLMLVTTTAFPTSQVRRGDFTEDTTPNRPVYTTSQVGGLITHVLWEIVEMRKELCNGNSDCMNNDDALAENNLKLPEIQRNDGCYQTGYNQEICLLKISSGLLEYHSYLEYMKNNLKDNKKDKARVLQRDTETLIHIFNQEVKDLHKIVLPTPISNALLTDKLESQKEWLRTKTIQFILKSLEEFLKVTLRSTRQT
Tissue specificity：Expressed by dendritic cells and macrophages (PubMed:27893700, PubMed:23045607). Expressed by activated follicular B cells (PubMed:23045607). Abundantly expressed in the central nervous system (CNS), particularly the hypothalamic region (PubMed:28402851). {ECO:0000269|PubMed:23045607, ECO:0000269|PubMed:27893700, ECO:0000269|PubMed:28402851}.
Induction：In activated follicular B cells, expression is induced early after influenza virus infection (PubMed:23045607). Plasma levels are highly increased upon exercise, due to enhanced production by contracting skeletal muscles (PubMed:22037645). {ECO:0000269|PubMed:22037645, ECO:0000269|PubMed:23045607}.
Developmental stage：
Protein families：IL-6 superfamily