BACE1_MOUSE P56818
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UniProt:P56818
Recommended name：Beta-secretase 1
EC number：EC 3.4.23.46
Alternative names：(Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2)
Cleaved into：
GeneID：23821
Gene names (primary )：Bace1
Gene names (synonym )：Bace
Gene names (ORF )：
Length：501
Mass：55748
Sequence：MAPALHWLLLWVGSGMLPAQGTHLGIRLPLRSGLAGPPLGLRLPRETDEESEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAGFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK
Tissue specificity：Expressed in the brain, specifically in neurons and astrocytes (at protein level). {ECO:0000269|PubMed:29325091}.
Induction：In brain oxidative stress induced by amyloid-beta deposition during aging increases protein levels. {ECO:0000269|PubMed:26467158}.
Developmental stage：
Protein families：Peptidase A1 family