TGTP1_MOUSE Q62293
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UniProt:Q62293
Recommended name：T-cell-specific guanine nucleotide triphosphate-binding protein 1
EC number：EC 3.6.5.-
Alternative names：(Interferon-gamma-inducible GTPase Ifggb5)
Cleaved into：
GeneID：100039796
Gene names (primary )：Tgtp1
Gene names (synonym )：Ifggb5 Irgb6 Mg21
Gene names (ORF )：
Length：415
Mass：47121
Sequence：MAWASSFDAFFKNFKRESKIISEYDITLIMTYIEENKLQKAVSVIEKVLRDIESAPLHIAVTGETGAGKSTFINTLRGVGHEEKGAAPTGAIETTMKRTPYPHPKLPNVTIWDLPGIGTTNFTPQNYLTEMKFGEYDFFIIISATRFKENDAQLAKAIAQMGMNFYFVRTKIDSDLDNEQKFKPKSFNKEEVLKNIKDYCSNHLQESLDSEPPVFLVSNVDISKYDFPKLETKLLQDLPAHKRHVFSLSLQSLTEATINYKRDSLKQKVFLEAMKAGALATIPLGGMISDILENLDETFNLYRSYFGLDDASLENIAQDLNMSVDDFKVHLRFPHLFAEHNDESLEDKLFKYIKHISSVTGGPVAAVTYYRMAYYLQNLFLDTAANDAIALLNSKALFEKKVGPYISEPPEYWEA
Tissue specificity：Expressed in thymus and lymph nodes, predominantly T-cells. Not expressed by immature CD4(+) CD8(+) thymocytes (at protein level) (PubMed:7836757). Expressed in IFNG-stimulated macrophages (PubMed:7884320). Expressed at low levels in unstimulated astrocytes (PubMed:19285957). Due to sequence similarity with Tgtp2, it is impossible to assign unambiguously experimental data published in the literature to Tgtp1 or Tgtp2 gene. {ECO:0000269|PubMed:19285957, ECO:0000269|PubMed:7836757, ECO:0000269|PubMed:7884320}.
Induction：In macrophages, up-regulated by IFNG, but not by IL2, IL4, IL10, nor TNF (PubMed:7884320). Up-regulated by IFNG in lymph node cells and thymocytes and other cell types (PubMed:7836757, PubMed:9725230, PubMed:24563254). In astrocytes, up-regulated by TNF and IFNG; when both cytokines are combined, the effect is synergistic (PubMed:19285957). Due to sequence similarity with Tgtp2, it is impossible to assign unambiguously experimental data published in the literature to Tgtp1 or Tgtp2 gene (Probable). {ECO:0000269|PubMed:19285957, ECO:0000269|PubMed:24563254, ECO:0000269|PubMed:7836757, ECO:0000269|PubMed:7884320, ECO:0000269|PubMed:9725230, ECO:0000305|PubMed:22892676}.
Developmental stage：
Protein families：TRAFAC class dynamin-like GTPase superfamily, IRG family