GRN_MOUSE P28798
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UniProt:P28798
Recommended name：Progranulin
EC number：
Alternative names：(PGRN) (Acrogranin) (Epithelin/granulin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI)
Cleaved into：Paragranulin; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7
GeneID：14824
Gene names (primary )：Grn
Gene names (synonym )：
Gene names (ORF )：
Length：589
Mass：63458
Sequence：MWVLMSWLAFAAGLVAGTQCPDGQFCPVACCLDQGGANYSCCNPLLDTWPRITSHHLDGSCQTHGHCPAGYSCLLTVSGTSSCCPFSKGVSCGDGYHCCPQGFHCSADGKSCFQMSDNPLGAVQCPGSQFECPDSATCCIMVDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHTRCVSPTGTHTLLKKFPAQKTNRAVSLPFSVVCPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCLSKNYTTDLLTKLPGYPVKEVKCDMEVSCPEGYTCCRLNTGAWGCCPFAKAVCCEDHIHCCPAGFQCHTEKGTCEMGILQVPWMKKVIAPLRLPDPQILKSDTPCDDFTRCPTNNTCCKLNSGDWGCCPIPEAVCCSDNQHCCPQGFTCLAQGYCQKGDTMVAGLEKIPARQTTPLQIGDIGCDQHTSCPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTCEKDVDFIQPPVLLTLGPKVGNVECGEGHFCHDNQTCCKDSAGVWACCPYLKGVCCRDGRHCCPGGFHCSARGTKCLRKKIPRWDMFLRDPVPRPLL
Tissue specificity：Highly expressed at the wound site and diminishes away from the wound. Not expressed in fibroblasts and endothelial cells in intact skin (PubMed:12524533). In adult brain, expressed primarily in neurons and in resting and reactive microglia (PubMed:23041626). Expressed in both neurons and microglia. Highly expressed in activated microglia in response to injury (PubMed:28541286). Expressed in macrophage (PubMed:27789271). {ECO:0000269|PubMed:12524533, ECO:0000269|PubMed:23041626, ECO:0000269|PubMed:27789271, ECO:0000269|PubMed:28541286}.
Induction：Injury-stimulated induction in the fibroblasts and endothelial cells and by inflammatory cells entering the wound (PubMed:12524533). Injury-stimulated induction in neurons (PubMed:28453791). Strongly induced in activated microglial cells that surround motor neurons after peripheral axonal injury, but not by astrocytes (PubMed:21092856). Up-regulated in response to a cortical injury. Up-regulated in activated glia during normal aging (PubMed:28541286). Induced in response to inflammation (PubMed:27789271). {ECO:0000269|PubMed:12524533, ECO:0000269|PubMed:21092856, ECO:0000269|PubMed:27789271, ECO:0000269|PubMed:28453791, ECO:0000269|PubMed:28541286}.
Developmental stage：
Protein families：Granulin family