MP2K6_MOUSE P70236
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UniProt:P70236
Recommended name：Dual specificity mitogen-activated protein kinase kinase 6
EC number：EC 2.7.12.2
Alternative names：(MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (MEK 6) (SAPKK3)
Cleaved into：
GeneID：26399
Gene names (primary )：Map2k6
Gene names (synonym )：Prkmk6 Sapkk3
Gene names (ORF )：
Length：334
Mass：37432
Sequence：MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSADFVDFTSQCLKKNSKERPTYPELMQHPFFTVHESKAADVASFVKLILGD
Tissue specificity：
Induction：MSAPK14 can negatively regulate the stability of the MAP2K6/MKK6 mRNA and thus control the steady-state concentration of one of its upstream activator. {ECO:0000269|PubMed:12482988}.
Developmental stage：
Protein families：Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily