SIR3_MOUSE Q8R104
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UniProt:Q8R104
Recommended name：NAD-dependent protein deacetylase sirtuin-3
EC number：EC 2.3.1.286
Alternative names：(Regulatory protein SIR2 homolog 3) (SIR2-like protein 3) (mSIR2L3)
Cleaved into：
GeneID：64384
Gene names (primary )：Sirt3
Gene names (synonym )：Sir2l3
Gene names (ORF )：
Length：334
Mass：36615
Sequence：MALDPLGAVVLQSIMALSGRLALAALRLWGPGGGRRPISLCVGASGGFGGGGSSEKKFSLQDVAELLRTRACSRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKELYPGHYRPNVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFPGEDIWADVMADRVPRCPVCTGVVKPDIVFFGEQLPARFLLHMADFALADLLLILGTSLEVEPFASLSEAVQKSVPRLLINRDLVGPFVLSPRRKDVVQLGDVVHGVERLVDLLGWTQELLDLMQRERGKLDGQDR
Tissue specificity：Strongly expressed in liver and kidney (PubMed:11056054). Expressed in skeletal muscles (at protein level) (PubMed:23283301, PubMed:23835326). Weakly expressed in lung (PubMed:11056054). {ECO:0000269|PubMed:11056054, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:23835326}.
Induction：Sirt3 expression decreases by 50% in skeletal muscle upon fasting. {ECO:0000269|PubMed:23835326}.
Developmental stage：
Protein families：Sirtuin family, Class I subfamily