CJ090_MOUSE D2J0Y4
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UniProt:D2J0Y4
Recommended name:(E2-independent) E3 ubiquitin-conjugating enzyme FATS
EC number:EC 2.3.2.-
Alternative names:(Centrosomal protein C10orf90 homolog) (E2/E3 hybrid ubiquitin-protein ligase FATS) (Fragile-site associated tumor suppressor homolog) (FATS)
Cleaved into:
GeneID:71007
Gene names (primary ):D7Ertd443e
Gene names (synonym ):Fats
Gene names (ORF ):
Length:644
Mass:71521
Sequence:MISPVVISRLIDEKKSMENGAILPQAIAQPQLCPTKPALARRDGVSMHRRFALSPDRLGILTPSDDQGLETEPLSTGDNLGKGSHSGFSSITITARRVGPPASSLVWDTFRDPLCPKCKAKDALFQEPPVLAGDAHLCQHNRPFTCTESPSNGSVEGMKVFQAHSRLSARQDYWVTHTNDNEDSFSSDNSPSRKVPLVFSSCVHFRVSQQCPNAIYYLDKSLSVPLERPQIASPKMHRSVLSLSLRCSSHQLTADGVDSSANGEPISTALSQELSEGKQDLLGPQWGQPQGGHWKESPALVPVHLGSGTCPRTGSPPLENVKFADVGRNQVPVRKEKEDHATCTSSSHTNQLSIHIPGWSYRAETKVLSGSKKQQQEAQRTLPAFPVGQKTIKHFPPEGDSSPSSDGQPSILSESNERQHPYFMIPRVPLPGFYCPLQTGCASLQEDGAVQIETHFPKDYTCCDLVVKLKECEKNEDPTVTPEPSPATPSPSTPEGAQSSDPSEDSYEPLLASSMTLQEALEVHRPQFISRSQERLQKLKRMVQQRKTQQKESLGQKQSLLPVRANKKQFTIPHPLSDNLFKPKERCISEKEMHMRSKRIYNNLPEVKKKKEEQKKRMILQSNRLRAEVFKKQLLDQLLQRNAV
Tissue specificity:Highly expressed in testis. Weak expression found in brain, lung, heart, ovary, thymus, spleen and kidney. {ECO:0000269|PubMed:20843368}.
Induction:Upon DNA damage by agents such as ionizing radiation, UV and actinomycin D. Activated by p53/TP53. {ECO:0000269|PubMed:20843368}.
Developmental stage:
Protein families: