IRG1_MOUSE P54987
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UniProt:P54987
Recommended name：Cis-aconitate decarboxylase
EC number：EC 4.1.1.6
Alternative names：(CAD) (Aconitate decarboxylase) (Aconitate decarboxylase 1) (Cis-aconitic acid decarboxylase) (Immune-responsive gene 1 protein)
Cleaved into：
GeneID：16365
Gene names (primary )：Acod1
Gene names (synonym )：Irg1
Gene names (ORF )：
Length：488
Mass：53758
Sequence：MMLKSVTESFAGMIHGLKVNHLTDGIIRRSKRMILDSLGVGFLGTGTEVFHKVTQYSKIYSSNTSSTVWGRPDFRLPPTYAAFVNGVAVHSMDFDDTWHPATHPSGAVLPVLTALSEALPQIPKFSGLDLLLAFNVGIEVQGRLMHFSKEAKDIPKRFHPPSVVGTLGSAAAASKFLGLSLTKCREALAIAVSHAGAPIANAATQTKPLHIGNAAKHGMEATFLAMLGLQGNKQILDLGSGFGAFYANYSPEDLPSLDSHIWLLDQQDVAFKSFPAHLATHWVADAAAAVRKHLVTPERALFPADHIERIVLRIPDVQYVNRPFPDSEHEARHSFQYVACASLLDGSITVPSFHSQQVNRPQVRELLKKVKLEHPPDNPPSFDTLYCEISITLKDGTTFTERSDTFYGHWRKPLSQEDLRNKFRANASKMLCRDTVESLITVVEKLEDLEDCSVLTRLLKGPSVQDEASKLSSMSSFDHTTLPRFTNI
Tissue specificity：Expressed in LPS-tolerized macrophages (at protein level). Expressed in the luminal epithelial cells of pregnant uterus. Expressed in microglia and macrophage cells. {ECO:0000269|PubMed:14500577, ECO:0000269|PubMed:23609450, ECO:0000269|PubMed:23610393}.
Induction：Up-regulated after lipopolysaccharide (LPS) stimulation (PubMed:23609450, PubMed:23610393). Up-regulated in LPS-tolerized macrophage by LPS (PubMed:23609450, PubMed:23610393). Up-regulated synergistically by proinflammatory cytokines TNF and IFNG (PubMed:19014335). Up-regulated by proinflammatory cytokines IL1B and IFNB1 (PubMed:19014335). Up-regulated by progesterone and at the time of the embryo implantation (PubMed:14500577). Expression is activated by IRF1 in neurons in response to flavivirus infection in neurons (PubMed:30635240). {ECO:0000269|PubMed:14500577, ECO:0000269|PubMed:19014335, ECO:0000269|PubMed:23609450, ECO:0000269|PubMed:23610393, ECO:0000269|PubMed:30635240}.
Developmental stage：
Protein families：PrpD family