GRP1_MOUSE Q9Z1S3
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UniProt:Q9Z1S3
Recommended name：RAS guanyl-releasing protein 1
EC number：
Alternative names：(Calcium and DAG-regulated guanine nucleotide exchange factor II) (CalDAG-GEFII) (Ras guanyl-releasing protein)
Cleaved into：
GeneID：19419
Gene names (primary )：Rasgrp1
Gene names (synonym )：Rasgrp
Gene names (ORF )：
Length：795
Mass：90304
Sequence：MGTLGKAREAPRKPCHGSRAGPKARLEAKSTNSPLPAQPSLAQITQFRMMVSLGHLAKGASLDDLIDSCIQSFDADGNLCRNNQLLQVMLTMHRIIISSAELLQKVMNLYKDALEKNSPGVCLKICYFVRYWITEFWIMFKMDASLTSTMEEFQDLVKANGEETHCHLIDTTQINSRDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSCRNYDNYRRAYGECTHFKIPILGVHLKDLISLYEAMPDYLEDGKVNVQKLLALYNHINELVQLQEMAPPLDANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRIKSPAISTENISSVVPMSTLCPLGTKDLLHAPEEGSFIFQNGEIVDHSEESKDRTIMLLGVSSQKISVRLKRTVAHKSTQTESFPWVGGETTPGHFVLSSPRKSAQGALYVHSPASPCPSPALVRKRAFVKWENKESLIKPKPELHLRLRTYQELEQEINTLKADNDALKIQLKYAQKKIESLQLGKSNHVLAQMDHGDSA
Tissue specificity：Detected in spleen and thymus. Expressed by mature thymocytes and to a lower extent by bone marrow-derived mast cells (at protein level). Detected in B-cells and keratinocytes (at protein level). {ECO:0000269|PubMed:11017103, ECO:0000269|PubMed:12433368, ECO:0000269|PubMed:14532295, ECO:0000269|PubMed:14970203, ECO:0000269|PubMed:17190838, ECO:0000269|PubMed:9819387}.
Induction：Up-regulated at the double-negative to double-positive transition during thymocyte development. Down-regulated by 12-O-tetradecanoylphorbol-13-acetate (TPA). {ECO:0000269|PubMed:12538669, ECO:0000269|PubMed:14532295}.
Developmental stage：
Protein families：RASGRP family