NGP_MOUSE   O08692


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UniProt:O08692

Recommended name:Neutrophilic granule protein

EC number:

Alternative names:(NGP) (Cystatin-like protein) (Myeloid bactenecin protein) (Myeloid secondary granule protein)

Cleaved into:

GeneID:18054

Gene names  (primary ):Ngp

Gene names  (synonym ):

Gene names  (ORF ):

Length:167

Mass:19332

Sequence:MAGLWKTFVLVVALAVVSCEALRQLRYEEIVDRAIEAYNQGRQGRPLFRLLSATPPSSQNPATNIPLQFRIKETECTSTQERQPKDCDFLEDGEERNCTGKFFRRRQSTSLTLTCDRDCSREDTQETSFNDKQDVSEKEKFEDVPPHIRNIYEDAKYDIIGNILKNF

Tissue specificity:Expressed in myeloid bone marrow cells. Expressed in neutrophilic precursors (at protein level) (PubMed:8749713). Expressed in myeloid bone marrow cells (PubMed:21518852). {ECO:0000269|PubMed:21518852, ECO:0000269|PubMed:8749713}.

Induction:Up-regulated by CCAAT/enhancer-binding proteins CEBPA and CEBPE and transcription factor SPI1 (at protein level) (PubMed:12515729). Down-regulated in malignant tumor conditioned medium (PubMed:21518852). Up-regulated during early bone marrow differentiation by the granulocyte-macrophage colony-stimulating factor CSF2 and down-regulated during granulocytic maturation (PubMed:8749713). {ECO:0000269|PubMed:12515729, ECO:0000269|PubMed:21518852, ECO:0000269|PubMed:8749713}.

Developmental stage:

Protein families:Cathelicidin family


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