HUMMR_MOUSE Q8VI64
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UniProt:Q8VI64
Recommended name：Protein MGARP
EC number：
Alternative names：(Corneal endothelium-specific protein 1) (CESP-1) (Hypoxia up-regulated mitochondrial movement regulator protein) (Mitochondria-localized glutamic acid-rich protein) (Ovary-specific acidic protein)
Cleaved into：
GeneID：67749
Gene names (primary )：Mgarp
Gene names (synonym )：Cesp1 Hummr Osap
Gene names (ORF )：
Length：283
Mass：29925
Sequence：MYLRRAVSKTLALPRRAPPGPAPLGKDASLRRMSSRKFPGTSGSNMIYYLVVGVTVSAGGYYTYKALTSKQVRRTEHVAEPKEQTKAELQPLPGEKEEHVAEAEQVCSEPGDTAVTEAESVDAEEVPEAAVVLPEESQASAPSEVPAEAAVVEASLSSSEPELKITEASLVETTESVPESTQEVESAAPDQDDVCNEGADTSQEGADTSQEGADTSQEGADTTKEEADNSKEAEGTTTEDPRSISEESAELEESPPLGSEPPAQPESQEEETQVTEETASPQG
Tissue specificity：Expressed in the ovary, testis, brain, adrenal glands and the compartments of the visual nervous system. Expressed in corneal endothelium (CE) (at protein level). Expressed in steroidogenic tissues with the highest level of expression observed in the adrenal gland. Weakly expressed in placenta. Weakly expressed in astrocytes and neurons under normoxia. Strongly expressed in astrocytes and neurons under hypoxia. Expressed in each layer of the retina, with particularly higher staining in the inner segment of the photoreceptor (IS), the outer plexiform layer (OPL) and the ganglion cell layer (GCL). {ECO:0000269|PubMed:16565373, ECO:0000269|PubMed:19325000, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20107910, ECO:0000269|PubMed:21447634}.
Induction：Up-regulated by chorionic gonadotropin in ovary. Up-regulated by hypoxia in a HIF-1A-dependent manner in neurons and astrocytes. Up-regulated during gonad development after birth, probably under the regulation of hormones derived from the hypothalamic-pituitary-gonadal (HPG) axis. {ECO:0000269|PubMed:19325000, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20107910}.
Developmental stage：
Protein families：