TIGAR_MOUSE Q8BZA9
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UniProt:Q8BZA9
Recommended name：Fructose-2,6-bisphosphatase TIGAR
EC number：EC 3.1.3.46
Alternative names：(TP53-induced glycolysis and apoptosis regulator) (TP53-induced glycolysis regulatory phosphatase)
Cleaved into：
GeneID：319801
Gene names (primary )：Tigar
Gene names (synonym )：
Gene names (ORF )：
Length：269
Mass：29191
Sequence：MPRFALTVIRHGETRLNKEKIIQGQGVDAPLSETGFRQAAAAGQFLSNVQFTHAFSSDLTRTKQTIHGILEKSRFCKDMAVKYDSRLRERMYGVAEGKPLSELRAMAKAAGEECPMFTPPGGETVEQVKMRGKDFFDFICQLILGKAGQRESVLPGAPGSGLESSLAEVFPVGKHGSLGANPKGGTLGLAASILVVSHGAYMRSLFGYFLSDLRCSLPGARDKLELSSITPNTGISVFIIDCEEARQPSIQCVCMNLQEHLNGVTEKQH
Tissue specificity：Expressed in olfactory bulb, cerebellum, and cortex (PubMed:24872551). Expressed in neurons and astrocytes (PubMed:24872551) (at protein level). Expressed in intestinal crypt (PubMed:23726973). {ECO:0000269|PubMed:23726973, ECO:0000269|PubMed:24872551}.
Induction：Up-regulated by hypoxia in cardiac myocytes in a p53/TP53-dependent manner (PubMed:20935145). Up-regulated in ischemic cortex after reperfusion in a p53/TP5-independent manner (PubMed:24872551). Up-regulated in primary neurons by oxygen and glucose deprivation (OGD)/reoxygenation insult in a p53/TP5-independent manner (at protein level) (PubMed:24872551). Up-regulated in ischemic myocardium in a p53/TP5-dependent manner (PubMed:22044588). Up-regulated in small intestine after gamma irradiation damage (PubMed:23726973). {ECO:0000269|PubMed:20935145, ECO:0000269|PubMed:22044588, ECO:0000269|PubMed:23726973, ECO:0000269|PubMed:24872551}.
Developmental stage：
Protein families：Phosphoglycerate mutase family