CASP4_MOUSE P70343
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UniProt:P70343
Recommended name：Caspase-4
EC number：EC 3.4.22.64
Alternative names：(CASP-4) (Caspase-11) (CASP-11) (Protease ICH-3)
Cleaved into：Caspase-4 subunit p10; Caspase-4 subunit p20
GeneID：12363
Gene names (primary )：Casp4
Gene names (synonym )：Casp11 Caspl Ich3
Gene names (ORF )：
Length：373
Mass：42742
Sequence：MAENKHPDKPLKVLEQLGKEVLTEYLEKLVQSNVLKLKEEDKQKFNNAERSDKRWVFVDAMKKKHSKVGEMLLQTFFSVDPGSHHGEANLEMEEPEESLNTLKLCSPEEFTRLCREKTQEIYPIKEANGRTRKALIICNTEFKHLSLRYGANFDIIGMKGLLEDLGYDVVVKEELTAEGMESEMKDFAALSEHQTSDSTFLVLMSHGTLHGICGTMHSEKTPDVLQYDTIYQIFNNCHCPGLRDKPKVIIVQACRGGNSGEMWIRESSKPQLCRGVDLPRNMEADAVKLSHVEKDFIAFYSTTPHHLSYRDKTGGSYFITRLISCFRKHACSCHLFDIFLKVQQSFEKASIHSQMPTIDRATLTRYFYLFPGN
Tissue specificity：Widely expressed, including in thymus, lung and spleen (at protein level). Very low levels, if any, in the brain. {ECO:0000269|PubMed:8702803, ECO:0000269|PubMed:9038361}.
Induction：Up-regulated by LPS and E.coli (PubMed:8702803, PubMed:10986288, PubMed:22002608, PubMed:26375259). In LPS-induced lung inflammation, markedly up-regulated after 6 hours of treatment and decreases at 24 hours. The induction is dependent upon DDIT3/CHOP-mediated ER stress (at protein level) (PubMed:16670335). In the spleen and in bone marrow-derived macrophages, up-regulated by poly(I:C), a synthetic analog of double-stranded RNA (at protein level) (PubMed:26320999, PubMed:26375259). Also induced by IFNG and interferon-alpha. Up-regulated by R848, a TLR7 synthetic activator, and Pam3CysK4, a synthetic activator of TLR1/TLR2 (PubMed:26375259). {ECO:0000269|PubMed:10986288, ECO:0000269|PubMed:16670335, ECO:0000269|PubMed:22002608, ECO:0000269|PubMed:26320999, ECO:0000269|PubMed:26375259, ECO:0000269|PubMed:8702803}.
Developmental stage：
Protein families：Peptidase C14A family