IRGM1_MOUSE Q60766
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UniProt:Q60766
Recommended name：Immunity-related GTPase family M protein 1
EC number：EC 3.6.5.-
Alternative names：(Interferon-inducible GTPase 3) (Interferon-inducible protein 1) (LPS-stimulated RAW 264.7 macrophage protein 47) (LRG-47)
Cleaved into：
GeneID：15944
Gene names (primary )：Irgm1
Gene names (synonym )：Ifi1 Iigp3 Irgm
Gene names (ORF )：
Length：409
Mass：46552
Sequence：MKPSHSSCEAAPLLPNMAETHYAPLSSAFPFVTSYQTGSSRLPEVSRSTERALREGKLLELVYGIKETVATLSQIPVSIFVTGDSGNGMSSFINALRVIGHDEDASAPTGVVRTTKTRTEYSSSHFPNVVLWDLPGLGATAQTVEDYVEEMKFSTCDLFIIIASEQFSSNHVKLSKIIQSMGKRFYIVWTKLDRDLSTSVLSEVRLLQNIQENIRENLQKEKVKYPPVFLVSSLDPLLYDFPKLRDTLHKDLSNIRCCEPLKTLYGTYEKIVGDKVAVWKQRIANESLKNSLGVRDDDNMGECLKVYRLIFGVDDESVQQVAQSMGTVVMEYKDNMKSQNFYTLRREDWKLRLMTCAIVNAFFRLLRFLPCVCCCLRRLRHKRMLFLVAQDTKNILEKILRDSIFPPQI
Tissue specificity：Expressed in lung and primary macrophages. {ECO:0000269|PubMed:14576437}.
Induction：Up-regulated by LPS and IFNG (at protein level). Up-regulated upon infection by various pathogens including T.cruzi, T.gondii, L.monocytogenes, M.tuberculosis and murine cytomegalovirus. {ECO:0000269|PubMed:11457893, ECO:0000269|PubMed:14576437, ECO:0000269|PubMed:14707092, ECO:0000269|PubMed:15294976, ECO:0000269|PubMed:16339555, ECO:0000269|PubMed:17911638, ECO:0000269|PubMed:7561525}.
Developmental stage：
Protein families：TRAFAC class dynamin-like GTPase superfamily, IRG family