TTP_MOUSE P22893
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UniProt:P22893
Recommended name：mRNA decay activator protein ZFP36
EC number：
Alternative names：(Growth factor-inducible nuclear protein NUP475) (TPA-induced sequence 11) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36)
Cleaved into：
GeneID：22695
Gene names (primary )：Zfp36
Gene names (synonym )：Nup475 Tis11 Tis11a Ttp
Gene names (ORF )：
Length：319
Mass：33613
Sequence：MDLSAIYESLQSMSHDLSSDHGGTESLGGLWNINSDSIPSGVTSRLTGRSTSLVEGRSCGWVPPPPGFAPLAPRPGPELSPSPTSPTATPTTSSRYKTELCRTYSESGRCRYGAKCQFAHGLGELRQANRHPKYKTELCHKFYLQGRCPYGSRCHFIHNPTEDLALPGQPHVLRQSISFSGLPSGRRSSPPPPGFSGPSLSSCSFSPSSSPPPPGDLPLSPSAFSAAPGTPVTRRDPNQACCPSCRRSTTPSTIWGPLGGLARSPSAHSLGSDPDDYASSGSSLGGSDSPVFEAGVFGPPQTPAPPRRLPIFNRISVSE
Tissue specificity：Expressed in skeletal muscle satellite cells (PubMed:25815583). Strongly expressed in differentiated adipocytes compared to preadipocytes (at protein level) (PubMed:22701344). Expressed in embryonic stem cells (ESCs) (PubMed:24733888). Expressed in heart, placenta, kidney, intestine, liver, lung, thymus, fat and spleen (PubMed:2204625, PubMed:1699942). {ECO:0000269|PubMed:1699942, ECO:0000269|PubMed:2204625, ECO:0000269|PubMed:22701344, ECO:0000269|PubMed:24733888, ECO:0000269|PubMed:25815583}.
Induction：Up-regulated during adipocyte differentiation (PubMed:17288565, PubMed:22701344). Up-regulated transiently in response to fibroblast growth factor FGF4 in a MAPK-dependent manner in embryonic stem cells (ESCs) (PubMed:24733888). Up-regulated by interferons and/or lipopolysaccharide (LPS) in a STAT1- and p38 MAPK-dependent manner (PubMed:11533235, PubMed:16514065, PubMed:16508014, PubMed:16508015). Down-regulated in muscle satellite cells upon muscle injury (at protein level) (PubMed:25815583). Up-regulated by various mitogens (PubMed:7559666). Up-regulated by LPS and TNF-alpha (PubMed:9703499). Up-regulated by interferon IFN-gamma and/or LPS in a STAT1- and p38 MAPK-dependent manner (PubMed:15187092, PubMed:16514065). Up-regulated during adipocyte differentiation (PubMed:22701344). Up-regulated in keratinocytes during epidermal repair after wound healing (PubMed:20166898). Down-regulated during the conversion from quiescence to activated satellite cells upon muscle injury (PubMed:23046558, PubMed:25815583). {ECO:0000269|PubMed:11533235, ECO:0000269|PubMed:15187092, ECO:0000269|PubMed:16508014, ECO:0000269|PubMed:16508015, ECO:0000269|PubMed:16514065, ECO:0000269|PubMed:17288565, ECO:0000269|PubMed:20166898, ECO:0000269|PubMed:22701344, ECO:0000269|PubMed:23046558, ECO:0000269|PubMed:24733888, ECO:0000269|PubMed:25815583, ECO:0000269|PubMed:7559666, ECO:0000269|PubMed:9703499}.
Developmental stage：
Protein families：