GP183_MOUSE Q3U6B2
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UniProt:Q3U6B2
Recommended name：G-protein coupled receptor 183
EC number：
Alternative names：(Epstein-Barr virus-induced G-protein coupled receptor 2 homolog) (EBI2) (EBV-induced G-protein coupled receptor 2 homolog)
Cleaved into：
GeneID：321019
Gene names (primary )：Gpr183
Gene names (synonym )：Ebi2
Gene names (ORF )：
Length：357
Mass：40185
Sequence：MANNFTTPLATSHGNNCDLYAHHSTARVLMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSMNLVISDILFTTALPTRIAYYALGFDWRIGDALCRVTALVFYINTYAGVNFMTCLSIDRFFAVVHPLRYNKIKRIEYAKGVCLSVWILVFAQTLPLLLTPMSKEEGDKTTCMEYPNFEGTASLPWILLGACLLGYVLPITVILLCYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFILCFTPYHVAIIQHMIKMLCSPGALECGARHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMKMLKRQVSVSISSAVRSAPEENSREMTESQMMIHSKASNGR
Tissue specificity：Expressed in mature B-cells and increases in expression early after activation, before being down-regulated in germinal center B-cells (PubMed:19597478). Expressed in astrocytes (PubMed:25297897). Specifically expressed in CD4(+) dendritic cells but not in CD8(+) dendritic cells (PubMed:23682316, PubMed:23502855). Expressed in monocyte/osteoclasts precursors and mature osteoclasts (PubMed:26438360). {ECO:0000269|PubMed:19597478, ECO:0000269|PubMed:23502855, ECO:0000269|PubMed:23682316, ECO:0000269|PubMed:25297897, ECO:0000269|PubMed:26438360}.
Induction：Up-regulated during B-cell maturation in the bone marrow, and is expressed in mature recirculating B-cells in bone marrow, spleen and lymph nodes (PubMed:19597478). Up-regulated in B-cells after BCR and CD40 engagement (PubMed:19597478). Down-regulated by lipopolysaccharide (LPS) in astrocytes (PubMed:27166278). Expression is directly down-regulated by BCL6 (PubMed:25176650). {ECO:0000269|PubMed:19597478, ECO:0000269|PubMed:25176650, ECO:0000269|PubMed:27166278}.
Developmental stage：
Protein families：G-protein coupled receptor 1 family