SYVN1_MOUSE Q9DBY1
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UniProt:Q9DBY1
Recommended name：E3 ubiquitin-protein ligase synoviolin
EC number：EC 2.3.2.27
Alternative names：(RING-type E3 ubiquitin transferase synoviolin) (Synovial apoptosis inhibitor 1)
Cleaved into：
GeneID：74126
Gene names (primary )：Syvn1
Gene names (synonym )：Hrd1 Kiaa1810
Gene names (ORF )：
Length：612
Mass：67296
Sequence：MFRTAVMMAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMAVLYIQAFVLVFLLGKVMGKVFFGQLRAAEMEHLLERSWYAVTETCLAFTVFRDDFSPRFVALFTLLLFLKCFHWLAEDRVDFMERSPNISWLFHCRIVSLMFLLGILDFLFVSHAYHSILTRGASVQLVFGFEYAILMTMVLTIFIKYVLHSVDLQSENPWDNKAVYMLYTELFTGFIKVLLYMAFMTIMIKVHTFPLFAIRPMYLAMRQFKKAVTDAIMSRRAIRNMNTLYPDATPEELQAVDNVCIICREEMVTGAKRLPCNHIFHTSCLRSWFQRQQTCPTCRMDVLRASLPAQSPPPPEPADQGPPPAPHPQPLLPQPPNFPQGLLPPFPPGMFPLWPPMGPFPPVPPPPSSGEAAAPPPTSTAVSRPSGAATTTAAGTSTSAPAPGSVPGPEAGPAPGFPFPPPWMGMPLPPPFAFPPMPVPPAGFAGLTPEELRALEGHERQHLEARLQSLRNIHTLLDAAMLQINQYLTVLASLGPPRPATSVNPTEETASTVVSAAPSTSAPSSEAPTPSPGASPPIPEAEKPPAPESVGIVEELPEDGEPDAAELRRRRLQKLESPVAH
Tissue specificity：Widely expressed, with highest levels in bone, spleen, lung and testis. In the brain, present in neurons but not in glial cells. Up-regulated in synovial tissues from mice with collagen-induced arthritis (at protein level). Expressed in the liver (PubMed:30389664). {ECO:0000269|PubMed:12975321, ECO:0000269|PubMed:17059562, ECO:0000269|PubMed:30389664}.
Induction：Up-regulated in conditions of cerebral ischemia (PubMed:15519674). In the liver, induced in postprandial conditions (PubMed:30389664). {ECO:0000269|PubMed:15519674, ECO:0000269|PubMed:30389664}.
Developmental stage：
Protein families：HRD1 family