PRP19_MOUSE Q99KP6
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UniProt:Q99KP6
Recommended name：Pre-mRNA-processing factor 19
EC number：EC 2.3.2.27
Alternative names：(Nuclear matrix protein 200) (PRP19/PSO4 homolog) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)
Cleaved into：
GeneID：28000
Gene names (primary )：Prpf19
Gene names (synonym )：Prp19 Snev
Gene names (ORF )：
Length：504
Mass：55239
Sequence：MSLICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPINNQPLSEEQLIDIKVAHPIRPKPPSATSIPAILKALQDEWDAVMLHSFTLRQQLQTTRQELSHALYQHDAACRVIARLTKEVTAAREALATLKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPEIIQKLQDKATVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSTEQILATLKGHTKKVTSVVFHPSQELVFSASPDATIRIWSVPNTSCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL
Tissue specificity：Expressed in white and brown adipose tissues, brain and to a lower extent in liver, kidney, muscle, lung and spleen (at protein level). {ECO:0000269|PubMed:17118936}.
Induction：Up-regulated in differentiating adipocytes (PubMed:17118936). Isoform 2 maximal expression level during the neural differentiation of P19 cells treated with retinoic acid (RA) is estimated to be 2.5-fold of the expression level of the untreated cells and it is detected 1-2 days after RA treatment and it decreases steeply thereafter to the basal level. Isoform 2 expression level increases steeply after 1 day of RA treatment and is estimated to be 4.2-fold of the original level at 0 hours (PubMed:16352598). {ECO:0000269|PubMed:16352598, ECO:0000269|PubMed:17118936}.
Developmental stage：
Protein families：WD repeat PRP19 family