ABCG5_MOUSE Q99PE8
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UniProt:Q99PE8
Recommended name：ATP-binding cassette sub-family G member 5
EC number：EC 7.6.2.-
Alternative names：(Sterolin-1)
Cleaved into：
GeneID：27409
Gene names (primary )：Abcg5
Gene names (synonym )：
Gene names (ORF )：
Length：652
Mass：73244
Sequence：MGELPFLSPEGARGPHINRGSLSSLEQGSVTGTEARHSLGVLHVSYSVSNRVGPWWNIKSCQQKWDRQILKDVSLYIESGQIMCILGSSGSGKTTLLDAISGRLRRTGTLEGEVFVNGCELRRDQFQDCFSYVLQSDVFLSSLTVRETLRYTAMLALCRSSADFYNKKVEAVMTELSLSHVADQMIGSYNFGGISSGERRRVSIAAQLLQDPKVMMLDEPTTGLDCMTANQIVLLLAELARRDRIVIVTIHQPRSELFQHFDKIAILTYGELVFCGTPEEMLGFFNNCGYPCPEHSNPFDFYMDLTSVDTQSREREIETYKRVQMLECAFKESDIYHKILENIERARYLKTLPTVPFKTKDPPGMFGKLGVLLRRVTRNLMRNKQAVIMRLVQNLIMGLFLIFYLLRVQNNTLKGAVQDRVGLLYQLVGATPYTGMLNAVNLFPMLRAVSDQESQDGLYHKWQMLLAYVLHVLPFSVIATVIFSSVCYWTLGLYPEVARFGYFSAALLAPHLIGEFLTLVLLGIVQNPNIVNSIVALLSISGLLIGSGFIRNIQEMPIPLKILGYFTFQKYCCEILVVNEFYGLNFTCGGSNTSMLNHPMCAITQGVQFIEKTCPGATSRFTANFLILYGFIPALVILGIVIFKVRDYLISR
Tissue specificity：Detected in liver and jejunum (PubMed:12444248, PubMed:15040800, PubMed:18402465, PubMed:25378657). Detected on enterocyte villi (at protein level) (PubMed:15040800). Expressed in jejunum, ileum and, at lower level, in the liver (PubMed:11138003, PubMed:11907139, PubMed:11099417, PubMed:12444248, PubMed:25378657). {ECO:0000269|PubMed:11099417, ECO:0000269|PubMed:11138003, ECO:0000269|PubMed:11907139, ECO:0000269|PubMed:12444248, ECO:0000269|PubMed:15040800, ECO:0000269|PubMed:18402465, ECO:0000269|PubMed:25378657}.
Induction：Up-regulated in liver and small intestine by cholesterol feeding (PubMed:11099417). Up-regulated via the oxysterols receptor LXR/retinoic X receptor (LXR/RXR) pathway (PubMed:14657202). Endotoxin (LPS) significantly decreased mRNA levels in the liver but not in the small intestine (PubMed:12777468). {ECO:0000269|PubMed:11099417, ECO:0000269|PubMed:12777468, ECO:0000269|PubMed:14657202}.
Developmental stage：
Protein families：ABC transporter superfamily, ABCG family, Eye pigment precursor importer (TC 3.A.1.204) subfamily