PCFT_MOUSE Q6PEM8
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UniProt:Q6PEM8
Recommended name：Proton-coupled folate transporter
EC number：
Alternative names：(Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1)
Cleaved into：
GeneID：52466
Gene names (primary )：Slc46a1
Gene names (synonym )：D11Ertd18e Hcp1 Pcft
Gene names (ORF )：
Length：459
Mass：50089
Sequence：MEGRVSSVGSPHSFLNAPVLFRGPVEPLVFLANFALVLQGPLTTQYLWHRFSTELGYNGTRHRENCGNQSADPLMKEVETLTSHWTLYMNVGGFLVGLFWSTLLGAWSDRVGRRPLLVLASLGLLLQAVVSIFVVQLELHVGFFVLGRALCALLGDFNGLLAASFASVADVSSNHSRTFRMALLEACIGVAGTLASLLGGHWLRAQGYANPFWLALALLIVMALYAAFCFGETVKEPKSTRLFTLRHHRSIARLYVVPAPEKSRMHLALYSLAIFVVVTVHFGAQDILTLYELSAPLCWDSKLIGYGSAAQHLPYLTSLLGLRLLQFCLADTWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVTTPVIRAKLSKLVSESEQGALFSAVACVNSLAMLMASGIFNSIYPATLNFMKGFPFLLGAGLLFIPAILIGVLEKVNPHPEFQQFPQSP
Tissue specificity：Highly expressed in duodenum, especially in duodenal mucosa, the main site of intestinal heme absorption. Weakly expressed in the kidney. Not expressed in duodenum before weaning or in placenta. Weakly or not expressed in brain, heart, lung, skeletal muscle, testis and neonatal liver. {ECO:0000269|PubMed:16143108}.
Induction：Up-regulated in response to hypoxia, it is however unclear whether such up-regulation is direct or not. Not induced in the duodenum of iron-deficient mice. {ECO:0000269|PubMed:16143108}.
Developmental stage：
Protein families：Major facilitator superfamily, SLC46A family