ABCG2_MOUSE Q7TMS5
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UniProt:Q7TMS5
Recommended name：Broad substrate specificity ATP-binding cassette transporter ABCG2
EC number：EC 7.6.2.2
Alternative names：(ATP-binding cassette sub-family G member 2) (Breast cancer resistance protein 1 homolog) (Urate exporter) (CD antigen CD338)
Cleaved into：
GeneID：26357
Gene names (primary )：Abcg2
Gene names (synonym )：Abcp Bcrp1
Gene names (ORF )：
Length：657
Mass：72978
Sequence：MSSSNDHVLVPMSQRNNNGLPRTNSRAVRTLAEGDVLSFHHITYRVKVKSGFLVRKTVEKEILSDINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPKGLSGDVLINGAPQPAHFKCCSGYVVQDDVVMGTLTVRENLQFSAALRLPTTMKNHEKNERINTIIKELGLEKVADSKVGTQFIRGISGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGKLVFHGPAQKALEYFASAGYHCEPYNNPADFFLDVINGDSSAVMLNREEQDNEANKTEEPSKGEKPVIENLSEFYINSAIYGETKAELDQLPGAQEKKGTSAFKEPVYVTSFCHQLRWIARRSFKNLLGNPQASVAQLIVTVILGLIIGAIYFDLKYDAAGMQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFFGKVMSDLLPMRFLPSVIFTCVLYFMLGLKKTVDAFFIMMFTLIMVAYTASSMALAIATGQSVVSVATLLMTIAFVFMMLFSGLLVNLRTIGPWLSWLQYFSIPRYGFTALQYNEFLGQEFCPGFNVTDNSTCVNSYAICTGNEYLINQGIELSPWGLWKNHVALACMIIIFLTIAYLKLLFLKKYS
Tissue specificity：Highly expressed in kidney. Lower expression in liver, colon, heart, spleen, and placenta (PubMed:11036110). Expressed in mammary gland (PubMed:17145775). Expressed in intestinal villi and renal proximal tubules, hepatic bile canalicular membranes, and placental labyrinth cells (at protein level) (PubMed:12429862). {ECO:0000269|PubMed:11036110, ECO:0000269|PubMed:12429862, ECO:0000269|PubMed:17145775}.
Induction：Up-regulated upon hypoxia. {ECO:0000269|PubMed:15044468}.
Developmental stage：
Protein families：ABC transporter superfamily, ABCG family, Eye pigment precursor importer (TC 3.A.1.204) subfamily