AGRA2_MOUSE Q91ZV8
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UniProt:Q91ZV8
Recommended name：Adhesion G protein-coupled receptor A2
EC number：
Alternative names：(G-protein coupled receptor 124) (Tumor endothelial marker 5)
Cleaved into：
GeneID：78560
Gene names (primary )：Adgra2
Gene names (synonym )：Gpr124 Tem5
Gene names (ORF )：
Length：1336
Mass：143170
Sequence：MGAGGRRMPVPPARLLLLPLLPCLLLLAPGTRGAPGCPVPIRGCKCSGERPKGLSGGAHNPARRRVVCGGGDLPEPPDPGLLPNGTITLLLSNNKITGLRNGSFLGLSLLEKLDLRSNVISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIYSSLQPGVFDELPALKIVDFGTEFLTCDCRLRWLLPWARNHSLQLSERTLCAYPSALHAHALSSLQESQLRCEGALELHTHYLIPSLRQVVFQGDRLPFQCSASYLGNDTRIHWYHNGAPMESDEQAGIVLAENLIHDCTFITSELTLSHIGVWASGEWECSVSTVQGNTSKKVEIVVLETSASYCPAERVTNNRGDFRWPRTLAGITAYQSCLQYPFTSVPLSGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSGIVGALERIGGAALSPHAQHISVNSRNVALEAYLIKPHSYVGLTCTAFQRREVGVSGAQPSSVGQDAPVEPEPLADQQLRFRCTTGRPNISLSSFHIKNSVALASIQLPPSLFSTLPAALAPPVPPDCTLQLLVFRNGRLFRSHGNNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGADPMAAWWNQDGPGGWSSEGCRLRYSQPNVSSLYCQHLGNVAVLMELNAFPREAGGSGAGLHPVVYPCTALLLLCLFSTIITYILNHSSIHVSRKGWHMLLNLCFHMAMTSAVFVGGVTLTNYQMVCQAVGITLHYSSLSSLLWMGVKARVLHKELSWRAPPLEEGEAAPPGPRPMLRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILPITWIYFLCAGLHLRSHVAQNPKQGNRISLEPGEELRGSTRLRSSGVLLNDSGSLLATVSAGVGTPAPPEDGDGVYSPGVQLGALMTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPASPSASHVPARALPTATEDGSPVLGEGPASLKSSPSGSSGRAPPPPCKLTNLQVAQSQVCEASVAARGDGEPEPTGSRGSLAPRHHNNLHHGRRVHKSRAKGHRAGETGGKSRLKALRAGTSPGAPELLSSESGSLHNSPSDSYPGSSRNSPGDGLPLEGEPMLTPSEGSDTSAAPIAETGRPGQRRSASRDNLKGSGSALERESKRRSYPLNTTSLNGAPKGGKYEDASVTGAEAIAGGSMKTGLWKSETTV
Tissue specificity：Abundantly expressed in the vasculature of the developing embryo (PubMed:11559528, PubMed:21071672, PubMed:21282641). Expression in normal adult tissues is specifically vascular with endothelial expression in CNS, including brain and retina and more widespread pericyte expression in the brain and organs, including the kidney, pancreas and corpus luteum (PubMed:21071672). {ECO:0000269|PubMed:11559528, ECO:0000269|PubMed:21071672, ECO:0000269|PubMed:21282641}.
Induction：Up-regulated by the growth factors activin AB (INHBA: INHBB dimer) and TGFB1 in vitro. {ECO:0000269|PubMed:21282641}.
Developmental stage：At 10 dpc expressed in a wide variety of tissues with relatively more abundant expression in limb buds (PubMed:18848646). At 10.5-12.5 dpc, detected in vessels of the developing CNS and perineural vascular plexus (PNVP) (PubMed:21282641). Expressed in both endothelial cells and pericytes, most prominently in brain and neural tube, and to a lesser degrees in non-CNS embryonic organs, including the liver, heart, and kidney (PubMed:18848646, PubMed:21282641). Expressed also in embryonic epithelium of lung and esophagus and in mesenchyme (PubMed:18848646, PubMed:21282641). Detected in mesenchyme of the palatal shelf at 12.5 dpc (PubMed:21282641). {ECO:0000269|PubMed:18848646, ECO:0000269|PubMed:21282641}.
Protein families：G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily