ROBO3_MOUSE Q9Z2I4
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UniProt:Q9Z2I4
Recommended name：Roundabout homolog 3
EC number：
Alternative names：(Retinoblastoma-inhibiting gene 1 protein) (Rig-1)
Cleaved into：
GeneID：
Gene names (primary )：Robo3
Gene names (synonym )：Rbig1
Gene names (ORF )：
Length：1366
Mass：146054
Sequence：MLRYLLKTLLQMNLFADSLARDISNSSELLFGFNSSLAALNPSLLPPGDPSLNGSRVGPEDAMPRIVEQPPDLVVSRGEPATLPCRAEGRPRPNIEWYKNGARVATAREDPRAHRLLLPSGALFFPRIVHGRRSRPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVMECVPPKGHPEPLVTWKKGKIKLKEEEGRITIRGGKLMMSHTFKSDAGMYMCVASNMAGERESGAAELVVLERPSFLRRPINQVVLADAPVNFLCEVQGDPQPNLHWRKDDGELPAGRYEIRSDHSLWIDQVSSEDEGTYTCVAENSVGRAEASGSLSVHVPPQFVTKPQNQTVAPGANVSFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPMGRLLVSPRGQLNITEVKIGDGGYYVCQAVSVAGSILAKALLEIKGASIDGLPPIILQGPANQTLVLGSSVWLPCRVIGNPQPNIQWKKDERWLQGDDSQFNLMDNGTLHIASIQEMDMGFYSCVAKSSIGEATWNSWLRKQEDWGASPGPATGPSNPPGPPSQPIVTEVTANSITLTWKPNPQSGATATSYVIEAFSQAAGNTWRTVADGVQLETYTISGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVQTQDSSLSRPAEDPWKGQRGLAEVAVRMQEPTVLGPRTLQVSWTVDGPVQLVQGFRVSWRIAGLDQGSWTMLDLQSPHKQSTVLRGLPPGAQIQIKVQVQGQEGLGAESPFVTRSIPEEAPSGPPQGVAVALGGDRNSSVTVSWEPPLPSQRNGVITEYQIWCLGNESRFHLNRSAAGWARSVTFSGLLPGQIYRALVAAATSAGVGVASAPVLVQLPFPPAAEPGPEVSEGLAERLAKVLRKPAFLAGSSAACGALLLGFCAALYRRQKQRKELSHYTASFAYTPAVSFPHSEGLSGSSSRPPMGLGPAAYPWLADSWPHPPRSPSAQEPRGSCCPSNPDPDDRYYNEAGISLYLAQTARGANASGEGPVYSTIDPVGEELQTFHGGFPQHSSGDPSTWSQYAPPEWSEGDSGARGGQGKLLGKPVQMPSLSWPEALPPPPPSCELSCPEGPEEELKGSSDLEEWCPPVPEKSHLVGSSSSGACMVAPAPRDTPSPTSSYGQQSTATLTPSPPDPPQPPTDIPHLHQMPRRVPLGPSSPLSVSQPALSSHDGRPVGLGAGPVLSYHASPSPVPSTASSAPGRTRQVTGEMTPPLHGHRARIRKKPKALPYRREHSPGDLPPPPLPPPELRDKLALGSAGSRQHVFPRARAQWGEESGAGSASRGPTSSQRGPHPDGKESQGRGRGLEACRSPNSPQLPLDSCIWSTLKLSLVSFIPSK
Tissue specificity：Detected in embryonal spinal chord and hindbrain. {ECO:0000269|PubMed:10049565, ECO:0000269|PubMed:15084255}.
Induction：
Developmental stage：At 10.5 dpc is expressed in long stripes in the dorso-ventral part of the neural tube. Later at 11.5, 12.5 and 13.5 dpc expression gradually moves dorsally and medially towards the roof plate. At 11.5 dpc highly expressed in spinal chord commissural exons before crossing the floor plate. After midline crossing initially continues to be expressed but then gets down-regulated. {ECO:0000269|PubMed:14678835}.
Protein families：Immunoglobulin superfamily, ROBO family